MAPPFinder 1.0 Results for the Gene Ontology File: C:\MAPPFinder Additional Files\FVBN Developmental Data from CardioGenomics.gex !date: Mon May 06 14:10:59 EDT 2002 Statistics: 1775 Genes met the [embryo fold] < -1.2 AND[embryo permute p] < 0.05 criteria. 644 Genes did not link to a MGI term. 145 Genes did not link to a GO term. 1630 genes were used to calculate the results shown below. The z score is based on an N of 4574 and a R of 923 distinct genes. GOID GO Name GO Type Number Changed Number Measured Number in GO Percent Changed Percent Present Number Changed in Hierarchy Number Measured in Hierarchy Number in GO Hierarchy Percent Changed in Hierarchy Percent Present in Hierarchy z Score 0005739 mitochondrion C 75 155 243 48.4 63.8 88 187 293 47.1 63.8 9.351 0006631 fatty acid metabolism P 12 16 19 75 84.2 19 30 41 63.3 73.2 5.908 0005777 peroxisome C 18 29 42 62.1 69 18 29 42 62.1 69 5.638 0015078 hydrogen ion transporter F 0 0 0 0 0 11 15 33 73.3 45.5 5.137 0015077 monovalent inorganic cation transporter F 0 0 1 0 0 11 15 34 73.3 44.1 5.137 0005743 mitochondrial inner membrane C 5 13 16 38.5 81.2 19 36 60 52.8 60 4.892 0019866 inner membrane C 0 0 0 0 0 19 36 60 52.8 60 4.892 0006092 main pathways of carbohydrate metabolism P 0 0 0 0 0 20 39 50 51.3 78 4.86 0005746 mitochondrial electron transport chain complex C 2 4 7 50 57.1 10 14 32 71.4 43.8 4.785 0005740 mitochondrial membrane C 1 5 7 20 71.4 20 40 72 50 55.6 4.72 0006091 energy pathways P 0 0 0 0 0 23 50 66 46 75.8 4.574 0015980 energy derivation by oxidation of organic compounds P 0 0 0 0 0 23 50 66 46 75.8 4.574 0005737 cytoplasm C 25 107 188 23.4 56.9 231 903 1291 25.6 69.9 4.514 0006095 catabolic carbohydrate metabolism P 0 0 0 0 0 18 36 45 50 80 4.475 0015399 primary active transporter F 0 0 0 0 0 27 64 107 42.2 59.8 4.418 0008324 cation transporter F 0 3 4 0 0 17 36 61 47.2 59 4.058 0015075 ion transporter F 0 0 0 0 0 19 43 79 44.2 54.4 3.941 0004129 cytochrome c oxidase F 6 8 16 75 50 6 8 16 75 50 3.866 0015002 heme-copper terminal oxidase F 0 0 0 0 0 6 8 16 75 50 3.866 0016676 oxidoreductase, acting on heme group of donors, oxygen as acceptor F 0 0 0 0 0 6 8 16 75 50 3.866 0005751 respiratory chain complex IV C 0 0 0 0 0 6 8 16 75 50 3.866 0016675 oxidoreductase, acting on heme group of donors F 0 0 0 0 0 6 8 16 75 50 3.866 0006099 tricarboxylic acid cycle P 6 8 10 75 80 6 8 10 75 80 3.866 0005752 cytochrome c oxidase C 6 8 16 75 50 6 8 16 75 50 3.866 0005996 monosaccharide metabolism P 0 0 0 0 0 18 41 49 43.9 83.7 3.802 0019318 hexose metabolism P 0 0 0 0 0 18 41 49 43.9 83.7 3.802 0016491 oxidoreductase F 12 38 42 31.6 90.5 48 149 207 32.2 72 3.721 0006629 lipid metabolism P 6 15 19 40 78.9 42 127 167 33.1 76 3.671 0006869 lipid transport P 4 6 8 66.7 75 5 7 11 71.4 63.6 3.381 0006096 glycolysis P 10 23 28 43.5 82.1 12 26 32 46.2 81.2 3.309 0007031 peroxisome organization and biogenesis P 7 12 15 58.3 80 7 12 15 58.3 80 3.297 0006006 glucose metabolism P 3 8 8 37.5 100 15 36 42 41.7 85.7 3.225 0007515 lymph gland development P 8 15 17 53.3 88.2 8 15 17 53.3 88.2 3.204 0003819 major histocompatibility complex antigen F 13 30 54 43.3 55.6 13 30 54 43.3 55.6 3.17 0008283 cell proliferation P 8 16 22 50 72.7 10 21 34 47.6 61.8 3.14 0006959 humoral immune response P 7 16 55 43.8 29.1 15 37 79 40.5 46.8 3.098 0005975 carbohydrate metabolism P 9 32 49 28.1 65.3 31 95 135 32.6 70.4 3.056 0016903 oxidoreductase, acting on the aldehyde or oxo group of donors F 0 0 0 0 0 7 13 16 53.8 81.2 3.029 0006007 glucose catabolism P 0 0 0 0 0 12 28 34 42.9 82.4 2.999 0016052 carbohydrate catabolism P 0 0 0 0 0 12 28 35 42.9 80 2.999 0019320 hexose catabolism P 0 0 0 0 0 12 28 34 42.9 82.4 2.999 0005386 carrier F 8 46 53 17.4 86.8 40 131 196 30.5 66.8 2.996 0042127 regulation of cell proliferation P 0 0 0 0 0 5 8 15 62.5 53.3 2.985 0003811 complement component F 8 14 16 57.1 87.5 8 16 19 50 84.2 2.977 0006803 glutathione conjugation reaction P 4 6 7 66.7 85.7 4 6 7 66.7 85.7 2.839 0008284 positive control of cell proliferation P 4 6 10 66.7 60 4 6 10 66.7 60 2.839 0006927 killing transformed cells P 2 2 2 100 100 2 2 2 100 100 2.813 0004712 protein threonine/tyrosine kinase F 1 1 1 100 100 2 2 2 100 100 2.813 0005748 NADH dehydrogenase (ubiquinone) C 2 2 11 100 18.2 2 2 11 100 18.2 2.813 0008943 glyceraldehyde 3-phosphate dehydrogenase F 0 0 0 0 0 2 2 2 100 100 2.813 0004448 isocitrate dehydrogenase F 0 0 0 0 0 2 2 3 100 66.7 2.813 0004301 epoxide hydrolase F 2 2 2 100 100 2 2 2 100 100 2.813 0015081 sodium transporter F 0 0 0 0 0 2 2 10 100 20 2.813 0008220 necrosis P 2 2 3 100 66.7 2 2 3 100 66.7 2.813 0005747 respiratory chain complex I C 2 2 2 100 100 2 2 11 100 18.2 2.813 0006100 TCA intermediate metabolism P 0 0 0 0 0 2 2 3 100 66.7 2.813 0004767 sphingomyelin phosphodiesterase F 2 2 3 100 66.7 2 2 3 100 66.7 2.813 0016406 carnitine O-acyltransferase F 0 0 0 0 0 2 2 4 100 50 2.813 0007205 protein kinase C activation P 2 2 2 100 100 2 2 2 100 100 2.813 0004014 adenosylmethionine decarboxylase F 2 2 2 100 100 2 2 2 100 100 2.813 0016775 phosphotransferase, nitrogenous group as acceptor F 0 0 0 0 0 2 2 2 100 100 2.813 0019395 fatty acid oxidation P 0 0 0 0 0 2 2 4 100 50 2.813 0016271 tissue death P 0 0 0 0 0 2 2 3 100 66.7 2.813 0009492 Fe2S2 electron transfer carrier F 2 2 2 100 100 2 2 2 100 100 2.813 0008137 NADH2 dehydrogenase (ubiquinone) F 2 2 10 100 20 2 2 10 100 20 2.813 0004673 protein histidine kinase F 2 2 2 100 100 2 2 2 100 100 2.813 0008216 spermidine metabolism P 0 0 0 0 0 2 2 2 100 100 2.813 0004143 diacylglycerol kinase F 2 2 2 100 100 2 2 2 100 100 2.813 0016405 CoA-ligase F 0 0 0 0 0 2 2 4 100 50 2.813 0004365 glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) F 2 2 2 100 100 2 2 2 100 100 2.813 0008295 spermidine biosynthesis P 2 2 2 100 100 2 2 2 100 100 2.813 0006082 organic acid metabolism P 0 0 0 0 0 2 2 6 100 33.3 2.813 0005498 sterol carrier F 2 2 2 100 100 2 2 2 100 100 2.813 0006083 acetate metabolism P 0 0 1 0 0 2 2 6 100 33.3 2.813 0008088 axon cargo transport P 0 0 0 0 0 2 2 2 100 100 2.813 0008090 retrograde axon cargo transport P 2 2 2 100 100 2 2 2 100 100 2.813 0006084 acetyl-CoA metabolism P 1 1 1 100 100 2 2 5 100 40 2.813 0016885 ligase, forming carbon-carbon bonds F 0 0 0 0 0 2 2 3 100 66.7 2.813 0006597 spermine biosynthesis P 2 2 2 100 100 2 2 2 100 100 2.813 0006936 muscle contraction P 2 4 7 50 57.1 9 20 28 45 71.4 2.772 0016289 CoA hydrolase F 0 0 0 0 0 3 4 8 75 50 2.733 0000122 repression of transcription, from Pol II promoter P 3 4 11 75 36.4 3 4 11 75 36.4 2.733 0003995 acyl-CoA dehydrogenase F 3 4 5 75 80 3 4 6 75 66.7 2.733 0007622 rhythmic behavior P 3 4 5 75 80 3 4 5 75 80 2.733 0006637 acyl-CoA metabolism P 3 4 8 75 50 3 4 8 75 50 2.733 0016833 oxo-acid-lyase F 0 0 0 0 0 3 4 4 75 100 2.733 0006941 striated muscle contraction P 3 4 7 75 57.1 3 4 7 75 57.1 2.733 0015662 P-type ATPase F 2 3 4 66.7 75 5 9 11 55.6 81.8 2.647 0007517 muscle development P 10 29 36 34.5 80.6 13 34 43 38.2 79.1 2.633 0007498 mesoderm development P 0 2 4 0 0 28 90 111 31.1 81.1 2.61 0006813 potassium transport P 17 49 60 34.7 81.7 17 49 60 34.7 81.7 2.545 0016820 hydrolase, acting on acid anhydrides, - catalysing transmembrane movement of substances F 0 0 0 0 0 15 42 67 35.7 62.7 2.52 0016020 membrane C 119 555 690 21.4 80.4 279 1234 1771 22.6 69.7 2.489 0016651 oxidoreductase, acting on NADH or NADPH F 0 0 0 0 0 4 7 18 57.1 38.9 2.438 0004683 calmodulin regulated protein kinase F 0 1 2 0 0 4 7 8 57.1 87.5 2.438 0016627 oxidoreductase, acting on the CH-CH group of donors F 0 0 0 0 0 4 7 14 57.1 50 2.438 0005759 mitochondrial matrix C 2 3 4 66.7 75 9 22 33 40.9 66.7 2.428 0030001 metal ion transport P 0 0 0 0 0 24 77 100 31.2 77 2.423 0019205 nucleobase, nucleoside, nucleotide kinase F 0 0 0 0 0 7 16 19 43.8 84.2 2.353 0004364 glutathione transferase F 5 10 13 50 76.9 5 10 13 50 76.9 2.352 0016776 phosphotransferase, phosphate group as acceptor F 0 0 0 0 0 5 10 13 50 76.9 2.352 0015672 monovalent inorganic cation transport P 0 0 1 0 0 21 67 88 31.3 76.1 2.294 0015405 P-P-bond-hydrolyzis-driven transporter F 0 0 0 0 0 17 52 78 32.7 66.7 2.261 0004009 ATP-binding cassette (ABC) transporter F 7 22 35 31.8 62.9 11 30 50 36.7 60 2.257 0016637 oxidoreductase, acting on the CH-CH group of donors, other acceptors F 0 0 0 0 0 3 5 8 60 62.5 2.22 0003821 class II major histocompatibility complex antigen F 3 5 7 60 71.4 3 5 7 60 71.4 2.22 0008530 exogenous peptide receptor F 0 0 0 0 0 3 5 7 60 71.4 2.22 0006956 complement activation P 8 15 16 53.3 93.8 8 20 23 40 87 2.213 0005267 potassium channel F 14 44 55 31.8 80 15 45 56 33.3 80.4 2.209 0006812 cation transport P 12 38 51 31.6 74.5 28 98 135 28.6 72.6 2.092 0005605 basement lamina C 4 10 10 40 100 5 11 11 45.5 100 2.091 0016830 carbon-carbon lyase F 0 0 0 0 0 5 11 18 45.5 61.1 2.091 0005856 cytoskeleton C 33 108 142 30.6 76.1 57 223 306 25.6 72.9 2.053 0016064 humoral defense mechanism (sensu Vertebrata) P 0 1 1 0 0 8 21 24 38.1 87.5 2.05 0006118 electron transport P 25 87 106 28.7 82.1 25 87 113 28.7 77 2.008 0016706 oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors F 0 0 0 0 0 2 3 4 66.7 75 2.007 0006071 glycerol metabolism P 1 1 1 100 100 2 3 4 66.7 75 2.007 0003956 NAD(P)(+)-arginine ADP-ribosyltransferase F 2 3 3 66.7 100 2 3 3 66.7 100 2.007 0016877 ligase, forming carbon-sulfur bonds F 0 0 0 0 0 2 3 5 66.7 60 2.007 0016615 malate dehydrogenase F 1 2 2 50 100 2 3 3 66.7 100 2.007 0019798 procollagen-proline dioxygenase F 0 0 0 0 0 2 3 3 66.7 100 2.007 0004656 procollagen-proline,2-oxoglutarate-4-dioxygenase F 2 3 3 66.7 100 2 3 3 66.7 100 2.007 0005744 mitochondrial inner membrane translocase complex C 2 3 3 66.7 100 2 3 3 66.7 100 2.007 0016291 acyl-CoA thioesterase F 2 3 7 66.7 42.9 2 3 7 66.7 42.9 2.007 0004685 calcium/calmodulin-dependent protein kinase F 2 3 3 66.7 100 2 3 3 66.7 100 2.007 0004862 cAMP-dependent protein kinase inhibitor F 2 3 3 66.7 100 2 3 3 66.7 100 2.007 0016655 oxidoreductase, acting on NADH or NADPH, quinone or similar compound as acceptor F 0 0 0 0 0 2 3 12 66.7 25 2.007 0006641 triacylglycerol metabolism P 0 0 0 0 0 2 3 5 66.7 60 2.007 0004470 malic enzyme F 2 3 3 66.7 100 2 3 3 66.7 100 2.007 0006801 superoxide metabolism P 2 3 3 66.7 100 2 3 3 66.7 100 2.007 0006638 neutral lipid metabolism P 0 0 0 0 0 2 3 5 66.7 60 2.007 0005954 calcium/calmodulin-dependent protein kinase C 2 3 3 66.7 100 2 3 3 66.7 100 2.007 0016624 oxidoreductase, acting on the aldehyde or oxo group of donors, disulfide as acceptor F 2 3 3 66.7 100 2 3 4 66.7 75 2.007 0009055 electron carrier F 0 0 0 0 0 2 3 4 66.7 75 2.007 0015427 ABC-type efflux porter F 0 0 0 0 0 2 3 3 66.7 100 2.007 0008042 iron-sulfur electron transfer carrier F 2 3 4 66.7 75 2 3 4 66.7 75 2.007 0004029 aldehyde dehydrogenase (NAD+) F 2 3 5 66.7 60 2 3 5 66.7 60 2.007 0008286 insulin receptor signaling pathway P 2 3 5 66.7 60 2 3 5 66.7 60 2.007 0001502 cartilage condensation P 2 3 4 66.7 75 2 3 4 66.7 75 2.007 0000265 heterotrimeric G-protein GTPase, gamma-subunit F 2 3 5 66.7 60 2 3 5 66.7 60 2.007 0006066 alcohol metabolism P 0 0 0 0 0 2 3 4 66.7 75 2.007 0006596 polyamine biosynthesis P 0 1 2 0 0 2 3 4 66.7 75 2.007 0016721 oxidoreductase, acting on superoxide radicals as acceptor F 0 0 0 0 0 2 3 3 66.7 100 2.007 0004784 superoxide dismutase F 1 1 1 100 100 2 3 3 66.7 100 2.007 0008215 spermine metabolism P 0 1 1 0 0 2 3 3 66.7 100 2.007 0016803 ether hydrolase F 0 0 0 0 0 2 3 3 66.7 100 2.007 0004463 leukotriene-A4 hydrolase F 0 1 1 0 0 2 3 3 66.7 100 2.007 0006639 acylglycerol metabolism P 0 0 0 0 0 2 3 5 66.7 60 2.007 0005215 transporter F 15 76 84 19.7 90.5 96 400 554 24 72.2 1.993 0004730 pseudouridylate synthase F 1 1 1 100 100 1 1 1 100 100 1.989 0004849 uridine kinase F 1 1 1 100 100 1 1 1 100 100 1.989 0004634 phosphopyruvate hydratase F 1 1 3 100 33.3 1 1 3 100 33.3 1.989 0004333 fumarate hydratase F 1 1 1 100 100 1 1 1 100 100 1.989 0004505 phenylalanine 4-monooxygenase F 1 1 1 100 100 1 1 1 100 100 1.989 0008384 IkB kinase F 1 1 1 100 100 1 1 1 100 100 1.989 0008478 pyridoxal kinase F 1 1 1 100 100 1 1 1 100 100 1.989 0004485 methylcrotonyl-CoA carboxylase F 1 1 1 100 100 1 1 1 100 100 1.989 0016421 CoA carboxylase F 0 0 0 0 0 1 1 2 100 50 1.989 0004736 pyruvate carboxylase F 1 1 1 100 100 1 1 1 100 100 1.989 0004678 G-protein-coupled receptor phosphorylating protein kinase F 1 1 1 100 100 1 1 1 100 100 1.989 0008605 casein kinase II, regulator F 1 1 1 100 100 1 1 1 100 100 1.989 0004108 citrate (SI)-synthase F 1 1 1 100 100 1 1 1 100 100 1.989 0016659 oxidoreductase, acting on NADH or NADPH, other acceptor F 0 0 0 0 0 1 1 2 100 50 1.989 0004385 guanylate kinase F 1 1 1 100 100 1 1 3 100 33.3 1.989 0017140 lipoic acid synthase F 1 1 1 100 100 1 1 1 100 100 1.989 0004708 MAP kinase kinase F 1 1 1 100 100 1 1 1 100 100 1.989 0016416 O-palmitoyltransferase F 0 0 0 0 0 1 1 2 100 50 1.989 0004464 leukotriene-C4 synthase F 1 1 1 100 100 1 1 1 100 100 1.989 0004095 carnitine O-palmitoyltransferase F 1 1 2 100 50 1 1 2 100 50 1.989 0004419 hydroxymethylglutaryl-CoA lyase F 1 1 1 100 100 1 1 1 100 100 1.989 0004421 hydroxymethylglutaryl-CoA synthase F 1 1 1 100 100 1 1 1 100 100 1.989 0004366 glycerol-3-phosphate acyltransferase F 1 1 1 100 100 1 1 1 100 100 1.989 0004356 glutamate-ammonia ligase F 1 1 1 100 100 1 1 1 100 100 1.989 0003857 3-hydroxyacyl-CoA dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.989 0003955 NAD(P)H2 dehydrogenase (quinone) F 1 1 1 100 100 1 1 1 100 100 1.989 0003863 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) F 1 1 1 100 100 1 1 1 100 100 1.989 0016899 oxidoreductase, acting on the CH-OH group of donors, oxygen as acceptor F 0 0 0 0 0 1 1 2 100 50 1.989 0004855 xanthine oxidase F 1 1 1 100 100 1 1 1 100 100 1.989 0004854 xanthine dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.989 0004757 sepiapterin reductase F 1 1 1 100 100 1 1 1 100 100 1.989 0004450 isocitrate dehydrogenase (NADP+) F 1 1 2 100 50 1 1 2 100 50 1.989 0016667 oxidoreductase, acting on sulfur group of donors F 0 0 0 0 0 1 1 1 100 100 1.989 0004367 glycerol-3-phosphate dehydrogenase (NAD+) F 1 1 1 100 100 1 1 1 100 100 1.989 0016668 oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor F 0 0 0 0 0 1 1 1 100 100 1.989 0004031 aldehyde oxidase F 1 1 1 100 100 1 1 1 100 100 1.989 0016623 oxidoreductase, acting on the aldehyde or oxo group of donors, oxygen as acceptor F 0 0 0 0 0 1 1 1 100 100 1.989 0004138 deoxyguanosine kinase F 1 1 1 100 100 1 1 1 100 100 1.989 0004085 butyryl-CoA dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.989 0004466 long-chain acyl-CoA dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.989 0003997 acyl-CoA oxidase F 1 1 3 100 33.3 1 1 3 100 33.3 1.989 0004471 malate dehydrogenase (decarboxylating) F 1 1 1 100 100 1 1 1 100 100 1.989 0004473 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+) F 1 1 1 100 100 1 1 1 100 100 1.989 0004449 isocitrate dehydrogenase (NAD+) F 1 1 1 100 100 1 1 1 100 100 1.989 0016453 C-acetyltransferase F 0 0 0 0 0 1 1 1 100 100 1.989 0016681 oxidoreductase, acting on diphenols and related substances as donors, cytochrome as acceptor F 0 0 0 0 0 1 1 2 100 50 1.989 0016679 oxidoreductase, acting on diphenols and related substances as donors F 0 0 0 0 0 1 1 2 100 50 1.989 0003988 acetyl-CoA C-acyltransferase F 0 0 0 0 0 1 1 1 100 100 1.989 0016413 O-acetyltransferase F 0 0 0 0 0 1 1 2 100 50 1.989 0004092 carnitine O-acetyltransferase F 1 1 1 100 100 1 1 1 100 100 1.989 0003957 NAD(P)(+) transhydrogenase (B-specific) F 1 1 1 100 100 1 1 1 100 100 1.989 0008746 NAD(P)(+) transhydrogenase F 1 1 1 100 100 1 1 1 100 100 1.989 0008383 manganese superoxide dismutase F 1 1 1 100 100 1 1 1 100 100 1.989 0004145 diamine N-acetyltransferase F 1 1 1 100 100 1 1 1 100 100 1.989 0008121 ubiquinol-cytochrome c reductase F 1 1 2 100 50 1 1 2 100 50 1.989 0003985 acetyl-CoA C-acetyltransferase F 1 1 1 100 100 1 1 1 100 100 1.989 0003720 telomerase F 0 0 0 0 0 1 1 1 100 100 1.989 0003721 telomeric RNA reverse transcriptase F 1 1 1 100 100 1 1 1 100 100 1.989 0004770 sterol carrier protein X-related thiolase F 1 1 1 100 100 1 1 1 100 100 1.989 0016722 oxidoreductase, oxidizing metal ions F 0 0 0 0 0 1 1 2 100 50 1.989 0016724 oxidoreductase, oxidizing metal ions, oxygen as acceptor F 0 0 0 0 0 1 1 2 100 50 1.989 0004322 ferroxidase F 1 1 2 100 50 1 1 2 100 50 1.989 0004148 dihydrolipoamide dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.989 0008751 NAD(P)H2 dehydrogenase F 0 0 0 0 0 1 1 1 100 100 1.989 0018342 protein prenylation P 0 0 0 0 0 1 1 1 100 100 1.989 0006097 glyoxylate cycle P 1 1 2 100 50 1 1 2 100 50 1.989 0006101 citrate metabolism P 1 1 1 100 100 1 1 1 100 100 1.989 0006108 malate metabolism P 1 1 1 100 100 1 1 1 100 100 1.989 0001561 fatty acid alpha-oxidation P 1 1 1 100 100 1 1 1 100 100 1.989 0006635 fatty acid beta-oxidation P 1 1 3 100 33.3 1 1 3 100 33.3 1.989 0006672 ceramide metabolism P 1 1 1 100 100 1 1 1 100 100 1.989 0006670 sphingosine metabolism P 1 1 1 100 100 1 1 1 100 100 1.989 0009399 nitrogen fixation P 1 1 1 100 100 1 1 1 100 100 1.989 0006399 tRNA metabolism P 1 1 3 100 33.3 1 1 3 100 33.3 1.989 0006502 C-terminal protein prenylation P 1 1 1 100 100 1 1 1 100 100 1.989 0003796 lysozyme F 1 1 1 100 100 1 1 1 100 100 1.989 0006507 GPI anchor release P 1 1 1 100 100 1 1 1 100 100 1.989 0006768 biotin metabolism P 1 1 1 100 100 1 1 1 100 100 1.989 0018410 peptide/protein carboxyl-terminal blocking P 0 0 0 0 0 1 1 3 100 33.3 1.989 0001666 response to hypoxia P 1 1 1 100 100 1 1 1 100 100 1.989 0015755 fructose transport P 1 1 1 100 100 1 1 1 100 100 1.989 0015757 galactose transport P 1 1 1 100 100 1 1 1 100 100 1.989 0030301 cholesterol transport P 1 1 1 100 100 1 1 1 100 100 1.989 0015918 sterol transport P 0 0 0 0 0 1 1 1 100 100 1.989 0030539 male genital morphogenesis P 1 1 2 100 50 1 1 2 100 50 1.989 0030538 genital morphogenesis P 0 0 0 0 0 1 1 2 100 50 1.989 0007340 acrosome reaction P 1 1 2 100 50 1 1 2 100 50 1.989 0005573 telomerase RNA C 1 1 1 100 100 1 1 1 100 100 1.989 0006501 C-terminal fatty acid:protein modification P 0 0 0 0 0 1 1 1 100 100 1.989 0009105 lipoic acid biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.989 0009634 heavy metal sensitivity/resistance P 1 1 2 100 50 1 1 3 100 33.3 1.989 0009412 heavy metal response P 0 0 0 0 0 1 1 3 100 33.3 1.989 0007213 acetyl choline receptor signaling, muscarinic pathway P 1 1 2 100 50 1 1 2 100 50 1.989 0030261 chromosome condensation P 1 1 2 100 50 1 1 5 100 20 1.989 0006278 RNA dependent DNA replication P 1 1 1 100 100 1 1 1 100 100 1.989 0030322 membrane potential stabilization P 1 1 1 100 100 1 1 1 100 100 1.989 0006552 leucine catabolism P 1 1 1 100 100 1 1 1 100 100 1.989 0009083 branched chain family amino acid catabolism P 0 0 0 0 0 1 1 1 100 100 1.989 0006551 leucine metabolism P 0 0 0 0 0 1 1 1 100 100 1.989 0009081 branched chain family amino acid metabolism P 0 0 0 0 0 1 1 1 100 100 1.989 0006119 oxidative phosphorylation P 0 0 0 0 0 1 1 7 100 14.3 1.989 0006085 acetyl-CoA biosynthesis P 0 0 2 0 0 1 1 4 100 25 1.989 0006122 complex III (ubiquinone to cytochrome c) P 1 1 1 100 100 1 1 1 100 100 1.989 0006744 ubiquinone biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.989 0006651 diacylglycerol biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.989 0008611 ether lipid biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.989 0006003 fructose 2,6-bisphosphate metabolism P 1 1 1 100 100 1 1 1 100 100 1.989 0006000 fructose metabolism P 0 0 0 0 0 1 1 1 100 100 1.989 0008300 isoprenoid catabolism P 1 1 1 100 100 1 1 1 100 100 1.989 0009062 fatty acid catabolism P 1 1 1 100 100 1 1 1 100 100 1.989 0006515 degradation of misfolded or incompletely synthesized proteins P 1 1 1 100 100 1 1 1 100 100 1.989 0000273 lipoic acid metabolism P 0 0 0 0 0 1 1 1 100 100 1.989 0006743 ubiquinone metabolism P 0 0 0 0 0 1 1 1 100 100 1.989 0016272 prefoldin C 1 1 2 100 50 1 1 2 100 50 1.989 0006086 acetyl-CoA biosynthesis, from pyruvate P 1 1 2 100 50 1 1 2 100 50 1.989 0004284 acrosin F 1 1 1 100 100 1 1 1 100 100 1.989 0005697 holotelomerase C 0 0 0 0 0 1 1 1 100 100 1.989 0004621 glycoprotein phospholipase D F 1 1 1 100 100 1 1 1 100 100 1.989 0008889 glycerophosphodiester phosphodiesterase F 1 1 1 100 100 1 1 1 100 100 1.989 0004439 phosphatidylinositol-bisphosphatase F 1 1 1 100 100 1 1 1 100 100 1.989 0008195 phosphatidate phosphatase F 1 1 2 100 50 1 1 2 100 50 1.989 0004423 iduronate-2-sulfatase F 1 1 1 100 100 1 1 1 100 100 1.989 0016293 long-chain fatty-acyl-CoA hydrolase F 1 1 1 100 100 1 1 1 100 100 1.989 0003940 L-iduronidase F 1 1 1 100 100 1 1 1 100 100 1.989 0004192 cathepsin D F 1 1 1 100 100 1 1 1 100 100 1.989 0004213 cathepsin B F 1 1 1 100 100 1 1 1 100 100 1.989 0003876 AMP deaminase F 1 1 1 100 100 1 1 1 100 100 1.989 0004181 metallocarboxypeptidase F 0 0 0 0 0 1 1 2 100 50 1.989 0016822 hydrolase, acting on acid carbon-carbon bonds F 0 0 0 0 0 1 1 1 100 100 1.989 0008462 endopeptidase Clp F 1 1 1 100 100 1 1 1 100 100 1.989 0004342 glucosamine-6-phosphate isomerase F 1 1 1 100 100 1 1 1 100 100 1.989 0004751 ribose-5-phosphate isomerase F 1 1 1 100 100 1 1 1 100 100 1.989 0004667 prostaglandin-D synthase F 1 1 2 100 50 1 1 2 100 50 1.989 0004165 dodecenoyl-CoA delta-isomerase F 1 1 1 100 100 1 1 1 100 100 1.989 0004494 methylmalonyl-CoA mutase F 1 1 1 100 100 1 1 1 100 100 1.989 0016870 intramolecular transferase, transferring other groups F 0 0 0 0 0 1 1 1 100 100 1.989 0008111 alpha-methylacyl-CoA racemase F 1 1 1 100 100 1 1 1 100 100 1.989 0016858 racemase and epimerase, acting on other compounds F 0 0 0 0 0 1 1 1 100 100 1.989 0016854 racemase and epimerase F 0 0 0 0 0 1 1 3 100 33.3 1.989 0017050 D-erythro-sphingosine kinase F 1 1 1 100 100 1 1 1 100 100 1.989 0004182 carboxypeptidase A F 1 1 2 100 50 1 1 2 100 50 1.989 0005888 integral plasma membrane proteoglycan C 1 1 4 100 25 1 1 4 100 25 1.989 0004370 glycerol kinase F 1 1 1 100 100 1 1 1 100 100 1.989 0016011 dystroglycan complex C 1 1 1 100 100 1 1 1 100 100 1.989 0016010 dystrophin-associated glycoprotein complex C 0 0 0 0 0 1 1 1 100 100 1.989 0005851 eukaryotic translation initiation factor 2B complex C 1 1 1 100 100 1 1 1 100 100 1.989 0005962 isocitrate dehydrogenase (NAD+) C 1 1 1 100 100 1 1 1 100 100 1.989 0030062 TCA cycle enzyme complex C 0 0 0 0 0 1 1 1 100 100 1.989 0015008 ubiquinol-cytochrome c reductase C 1 1 1 100 100 1 1 1 100 100 1.989 0005750 respiratory chain complex III C 0 0 0 0 0 1 1 1 100 100 1.989 0005782 peroxisomal matrix C 1 1 2 100 50 1 1 2 100 50 1.989 0005778 peroxisomal membrane C 1 1 1 100 100 1 1 1 100 100 1.989 0004465 lipoprotein lipase F 1 1 1 100 100 1 1 1 100 100 1.989 0005915 zonula adherens C 1 1 1 100 100 1 1 1 100 100 1.989 0000015 enolase C 1 1 3 100 33.3 1 1 3 100 33.3 1.989 0030315 T-tubule C 1 1 1 100 100 1 1 1 100 100 1.989 0001527 microfibril C 1 1 1 100 100 1 1 1 100 100 1.989 0008318 protein prenyltransferase F 1 1 1 100 100 1 1 1 100 100 1.989 0003826 alpha-ketoacid dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.989 0003987 acetate-CoA ligase F 1 1 3 100 33.3 1 1 3 100 33.3 1.989 0004774 succinate-CoA ligase F 1 1 1 100 100 1 1 1 100 100 1.989 0015433 major histocompatibility peptide transporter F 1 1 1 100 100 1 1 1 100 100 1.989 0016467 hydrogen-translocating F-type ATPase F 1 1 1 100 100 1 1 1 100 100 1.989 0003998 acylphosphatase F 1 1 1 100 100 1 1 1 100 100 1.989 0004334 fumarylacetoacetase F 1 1 1 100 100 1 1 1 100 100 1.989 0016823 hydrolase, acting on acid carbon-carbon bonds, in ketonic substances F 0 0 0 0 0 1 1 1 100 100 1.989 0005665 DNA-directed RNA polymerase II, core C 1 1 2 100 50 1 1 2 100 50 1.989 0004935 adrenoceptor F 0 0 0 0 0 1 1 1 100 100 1.989 0004790 thioether S-methyltransferase F 1 1 1 100 100 1 1 1 100 100 1.989 0004105 cholinephosphate cytidylyltransferase F 1 1 1 100 100 1 1 1 100 100 1.989 0003901 DNA-directed RNA polymerase II F 1 1 2 100 50 1 1 2 100 50 1.989 0008108 UDP-glucose-hexose-1-phosphate uridylyltransferase F 1 1 1 100 100 1 1 1 100 100 1.989 0003982 UTP-hexose-1-phosphate uridylyltransferase F 1 1 1 100 100 1 1 1 100 100 1.989 0030023 extracellular matrix constituent conferring elasticity F 1 1 1 100 100 1 1 1 100 100 1.989 0008281 sulfonylurea receptor F 1 1 1 100 100 1 1 1 100 100 1.989 0005173 stem cell factor receptor ligand F 1 1 1 100 100 1 1 1 100 100 1.989 0001611 A2A adenosine receptor, G-protein coupled F 1 1 1 100 100 1 1 1 100 100 1.989 0004883 glucocorticoid receptor F 1 1 1 100 100 1 1 1 100 100 1.989 0030228 lipoprotein receptor F 0 0 0 0 0 1 1 3 100 33.3 1.989 0003908 methylated-DNA-[protein]-cysteine S-methyltransferase F 1 1 1 100 100 1 1 1 100 100 1.989 0005337 nucleoside transporter F 1 1 1 100 100 1 1 2 100 50 1.989 0001609 adenosine receptor, G-protein coupled F 0 0 0 0 0 1 1 1 100 100 1.989 0004936 alpha-adrenergic receptor F 0 0 0 0 0 1 1 1 100 100 1.989 0004937 alpha1-adrenergic receptor F 1 1 1 100 100 1 1 1 100 100 1.989 0015932 nucleobase, nucleoside, nucleotide and nucleic acid transporter F 0 0 0 0 0 1 1 3 100 33.3 1.989 0016975 alpha2-macroglobulin F 1 1 1 100 100 1 1 1 100 100 1.989 0017114 wide-spectrum protease inhibitor F 0 0 0 0 0 1 1 1 100 100 1.989 0015106 bicarbonate transporter F 0 0 0 0 0 1 1 2 100 50 1.989 0009374 biotin binding F 1 1 1 100 100 1 1 1 100 100 1.989 0008034 lipoprotein binding F 0 0 0 0 0 1 1 3 100 33.3 1.989 0030169 low-density lipoprotein binding F 0 0 0 0 0 1 1 3 100 33.3 1.989 0005041 low-density lipoprotein receptor F 1 1 3 100 33.3 1 1 3 100 33.3 1.989 0005536 glucose binding F 1 1 1 100 100 1 1 1 100 100 1.989 0005523 tropomyosin binding F 1 1 3 100 33.3 1 1 3 100 33.3 1.989 0004924 oncostatin-M receptor F 1 1 1 100 100 1 1 1 100 100 1.989 0005402 cation:sugar symporter F 0 0 0 0 0 1 1 1 100 100 1.989 0005355 glucose transporter F 1 1 2 100 50 1 1 2 100 50 1.989 0008516 hexose uniporter F 0 0 0 0 0 1 1 1 100 100 1.989 0015149 hexose transporter F 0 0 0 0 0 1 1 2 100 50 1.989 0003945 N-acetyllactosamine synthase F 1 1 1 100 100 1 1 1 100 100 1.989 0015145 monosaccharide transporter F 0 0 0 0 0 1 1 2 100 50 1.989 0000030 mannosyltransferase F 1 1 1 100 100 1 1 1 100 100 1.989 0005354 galactose transporter F 1 1 1 100 100 1 1 1 100 100 1.989 0005403 hydrogen:sugar symporter-transporter F 0 0 0 0 0 1 1 1 100 100 1.989 0008510 sodium:bicarbonate cotransporter F 1 1 1 100 100 1 1 1 100 100 1.989 0003831 beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase F 1 1 2 100 50 1 1 2 100 50 1.989 0015295 solute:hydrogen symporter F 0 0 0 0 0 1 1 1 100 100 1.989 0015292 uniporter F 0 0 0 0 0 1 1 1 100 100 1.989 0015270 dihydropyridine-sensitive calcium channel F 1 1 1 100 100 1 1 1 100 100 1.989 0016286 small conductance calcium-activated potassium channel F 1 1 2 100 50 1 1 2 100 50 1.989 0015269 calcium-activated potassium channel F 0 0 0 0 0 1 1 2 100 50 1.989 0005360 insulin-responsive hydrogen:glucose transporter F 1 1 1 100 100 1 1 1 100 100 1.989 0004587 ornithine-oxo-acid aminotransferase F 1 1 1 100 100 1 1 1 100 100 1.989 0005353 fructose transporter F 0 0 0 0 0 1 1 1 100 100 1.989 0015284 fructose uniporter F 1 1 1 100 100 1 1 1 100 100 1.989 0016792 phosphoric diester hydrolase F 0 0 0 0 0 7 18 32 38.9 56.2 1.982 0016766 transferring alkyl or aryl groups, other than methyl groups F 0 0 0 0 0 7 18 21 38.9 85.7 1.982 0016765 transferase, transferring alkyl or aryl (other than methyl) groups F 0 0 0 0 0 7 18 21 38.9 85.7 1.982 0005489 electron transporter F 3 5 5 60 100 9 25 30 36 83.3 1.976 0003824 enzyme F 28 95 111 29.5 85.6 301 1375 1896 21.9 72.5 1.891 0016021 integral membrane protein C 216 986 1245 21.9 79.2 239 1079 1479 22.2 73 1.845 0016614 oxidoreductase, CH-OH group of donors F 0 0 0 0 0 14 45 51 31.1 88.2 1.836 0003754 chaperone F 11 37 53 29.7 69.8 14 45 62 31.1 72.6 1.836 0005519 cytoskeletal regulatory protein binding F 3 6 8 50 75 3 6 8 50 75 1.821 0019748 secondary metabolism P 0 0 0 0 0 3 6 8 50 75 1.821 0019201 nucleotide kinase F 0 0 0 0 0 3 6 8 50 75 1.821 0006595 polyamine metabolism P 1 3 4 33.3 75 3 6 8 50 75 1.821 0006839 mitochondrial transport P 3 6 6 50 100 3 6 6 50 100 1.821 0016407 acetyltransferase F 0 3 3 0 0 4 9 14 44.4 64.3 1.815 0009063 amino acid catabolism P 1 1 1 100 100 4 9 12 44.4 75 1.815 0016620 oxidoreductase, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor F 0 1 1 0 0 4 9 11 44.4 81.8 1.815 0003714 transcription co-repressor F 4 9 17 44.4 52.9 4 9 17 44.4 52.9 1.815 0003707 steroid hormone receptor F 12 38 42 31.6 90.5 12 38 42 31.6 90.5 1.758 0004879 ligand-dependent nuclear receptor F 9 28 32 32.1 87.5 12 38 42 31.6 90.5 1.758 0003706 ligand-regulated transcription factor F 0 0 0 0 0 12 38 42 31.6 90.5 1.758 0016616 oxidoreductase, acting on the CH-OH group of donors, NAD or NADP as acceptor F 0 0 0 0 0 13 42 47 31 89.4 1.747 0008081 phosphodiesterase F 0 1 2 0 0 6 16 29 37.5 55.2 1.729 0008017 microtubule binding F 3 5 6 60 83.3 9 27 50 33.3 54 1.708 0015631 tubulin binding F 0 0 0 0 0 9 27 50 33.3 54 1.708 0005875 microtubule associated protein C 6 21 26 28.6 80.8 11 35 60 31.4 58.3 1.664 0006937 muscle contraction regulation P 5 13 13 38.5 100 5 13 13 38.5 100 1.645 0008092 cytoskeletal protein binding F 1 2 3 50 66.7 25 93 144 26.9 64.6 1.627 0008415 acyltransferase F 5 7 8 71.4 87.5 8 24 34 33.3 70.6 1.61 0005505 heavy metal binding F 5 12 14 41.7 85.7 17 60 81 28.3 74.1 1.584 0016747 transferase, transferring groups other than amino-acyl groups F 0 2 2 0 0 9 28 38 32.1 73.7 1.582 0019222 regulation of metabolism P 1 2 2 50 100 4 10 11 40 90.9 1.563 0005044 scavenger receptor F 4 10 16 40 62.5 4 10 16 40 62.5 1.563 0005604 basement membrane C 5 16 18 31.2 88.9 6 17 19 35.3 89.5 1.556 0009308 amine metabolism P 0 0 0 0 0 6 17 24 35.3 70.8 1.556 0006357 transcription regulation, from Pol II promoter P 3 13 27 23.1 48.1 6 17 38 35.3 44.7 1.556 0006800 oxygen and radical metabolism P 0 1 1 0 0 7 21 25 33.3 84 1.505 0019933 cAMP-mediated signaling P 1 2 2 50 100 7 21 26 33.3 80.8 1.505 0004005 plasma membrane cation-transporting ATPase F 3 7 14 42.9 50 3 7 14 42.9 50 1.496 0015406 ABC-type uptake permease F 0 0 0 0 0 3 7 14 42.9 50 1.496 0019829 cation-transporting ATPase F 0 0 0 0 0 3 7 14 42.9 50 1.496 0015646 permease F 0 0 0 0 0 3 7 14 42.9 50 1.496 0005106 ephrin F 3 7 8 42.9 87.5 3 7 8 42.9 87.5 1.496 0015563 uptake permease F 0 0 0 0 0 3 7 14 42.9 50 1.496 0016481 repression of transcription P 0 3 9 0 0 3 7 19 42.9 36.8 1.496 0006469 protein kinase inhibition P 2 4 4 50 100 2 4 4 50 100 1.487 0006559 phenylalanine catabolism P 2 4 5 50 80 2 4 5 50 80 1.487 0016861 intramolecular isomerase, interconverting aldoses and ketoses F 0 0 0 0 0 2 4 4 50 100 1.487 0004017 adenylate kinase F 2 4 4 50 100 2 4 4 50 100 1.487 0004024 alcohol dehydrogenase, zinc-dependent F 2 4 5 50 80 2 4 5 50 80 1.487 0016801 hydrolase, acting on ether bonds F 0 0 0 0 0 2 4 4 50 100 1.487 0016502 nucleotide receptor F 0 0 0 0 0 2 4 4 50 100 1.487 0008172 S-methyltransferase F 0 0 0 0 0 2 4 4 50 100 1.487 0009208 pyrimidine ribonucleoside triphosphate metabolism P 0 0 0 0 0 2 4 5 50 80 1.487 0009209 pyrimidine ribonucleoside triphosphate biosynthesis P 0 0 0 0 0 2 4 5 50 80 1.487 0004691 cAMP-dependent protein kinase F 0 0 0 0 0 2 4 5 50 80 1.487 0006228 UTP biosynthesis P 2 4 5 50 80 2 4 5 50 80 1.487 0005964 phosphorylase kinase C 2 4 4 50 100 2 4 4 50 100 1.487 0006241 CTP biosynthesis P 2 4 5 50 80 2 4 5 50 80 1.487 0004550 nucleoside-diphosphate kinase F 2 4 5 50 80 2 4 5 50 80 1.487 0006183 GTP biosynthesis P 2 4 5 50 80 2 4 5 50 80 1.487 0009145 purine nucleoside triphosphate biosynthesis P 0 0 0 0 0 2 4 5 50 80 1.487 0006558 phenylalanine metabolism P 0 0 0 0 0 2 4 5 50 80 1.487 0005391 sodium/potassium-exchanging ATPase F 2 4 5 50 80 2 4 5 50 80 1.487 0009144 purine nucleoside triphosphate metabolism P 0 0 0 0 0 2 4 5 50 80 1.487 0016564 transcriptional repressor F 2 3 13 66.7 23.1 2 4 14 50 28.6 1.487 0008603 cAMP-dependent protein kinase, regulator F 2 4 5 50 80 2 4 5 50 80 1.487 0004689 phosphorylase kinase F 2 3 3 66.7 100 2 4 4 50 100 1.487 0019932 second-messenger-mediated signaling P 0 0 0 0 0 9 29 42 31 69 1.461 0016049 cell growth P 2 3 4 66.7 75 5 14 19 35.7 73.7 1.45 0006958 complement activation, classical pathway P 5 14 14 35.7 100 5 14 14 35.7 100 1.45 0000313 organellar ribosome C 0 0 0 0 0 6 18 27 33.3 66.7 1.393 0005761 mitochondrial ribosome C 0 0 4 0 0 6 18 27 33.3 66.7 1.393 0006575 amino acid derivative metabolism P 0 0 0 0 0 6 18 25 33.3 72 1.393 0016829 lyase F 0 0 1 0 0 11 38 57 28.9 66.7 1.352 0004868 serpin F 9 30 36 30 83.3 9 30 36 30 83.3 1.345 0005520 insulin-like growth factor binding F 4 11 13 36.4 84.6 4 11 13 36.4 84.6 1.339 0019838 growth factor binding F 0 0 0 0 0 4 11 13 36.4 84.6 1.339 0009309 amine biosynthesis P 0 0 0 0 0 4 11 12 36.4 91.7 1.339 0005887 integral plasma membrane protein C 57 244 412 23.4 59.2 63 271 449 23.2 60.4 1.297 0007610 behavior P 0 1 3 0 0 5 15 21 33.3 71.4 1.271 0007188 G-protein signaling, coupled to cAMP nucleotide second messenger P 0 2 2 0 0 6 19 24 31.6 79.2 1.241 0006996 organelle organization and biogenesis P 0 0 0 0 0 34 140 203 24.3 69 1.229 0019935 cyclic-nucleotide-mediated signaling P 0 0 0 0 0 7 23 29 30.4 79.3 1.228 0005861 troponin complex C 3 8 8 37.5 100 3 8 8 37.5 100 1.222 0003820 class I major histocompatibility complex antigen F 3 8 9 37.5 88.9 3 8 9 37.5 88.9 1.222 0015036 disulfide oxidoreductase F 1 2 3 50 66.7 3 8 9 37.5 88.9 1.222 0008529 endogenous peptide receptor F 0 0 0 0 0 3 8 9 37.5 88.9 1.222 0007017 microtubule-based process P 12 44 70 27.3 62.9 14 52 82 26.9 63.4 1.219 0009056 catabolism P 0 1 1 0 0 54 232 300 23.3 77.3 1.206 0006811 ion transport P 20 88 115 22.7 76.5 37 155 215 23.9 72.1 1.165 0005261 cation channel F 9 29 34 31 85.3 22 88 114 25 77.2 1.138 0016790 thiolester hydrolase F 0 0 0 0 0 4 12 24 33.3 50 1.137 0030154 cell differentiation P 4 7 9 57.1 77.8 4 12 18 33.3 66.7 1.137 0016860 intramolecular isomerase F 0 0 0 0 0 4 12 13 33.3 92.3 1.137 0009108 coenzyme biosynthesis P 0 0 0 0 0 4 12 18 33.3 66.7 1.137 0016853 isomerase F 0 0 0 0 0 9 32 42 28.1 76.2 1.124 0015630 microtubule cytoskeleton C 0 1 1 0 0 13 49 77 26.5 63.6 1.114 0003702 RNA polymerase II transcription factor F 1 7 12 14.3 58.3 13 49 60 26.5 81.7 1.114 0008246 electron transfer flavoprotein F 5 16 19 31.2 84.2 5 16 19 31.2 84.2 1.105 0007018 microtubule-based movement P 3 14 18 21.4 77.8 5 16 20 31.2 80 1.105 0006171 cAMP biosynthesis P 2 5 7 40 71.4 2 5 7 40 71.4 1.105 0006583 melanin biosynthesis, from tyrosine P 2 5 5 40 100 2 5 5 40 100 1.105 0004690 cyclic-nucleotide dependent protein kinase F 0 0 0 0 0 2 5 7 40 71.4 1.105 0016528 sarcoplasm C 0 0 0 0 0 2 5 5 40 100 1.105 0009147 pyrimidine nucleoside triphosphate metabolism P 0 0 0 0 0 2 5 6 40 83.3 1.105 0019203 carbohydrate phosphatase F 0 0 0 0 0 2 5 5 40 100 1.105 0009148 pyrimidine nucleoside triphosphate biosynthesis P 0 0 0 0 0 2 5 6 40 83.3 1.105 0015749 monosaccharide transport P 0 0 0 0 0 2 5 6 40 83.3 1.105 0004028 aldehyde dehydrogenase F 0 2 2 0 0 2 5 7 40 71.4 1.105 0009074 aromatic amino acid family catabolism P 0 0 0 0 0 2 5 6 40 83.3 1.105 0005763 mitochondrial small ribosomal subunit C 2 5 7 40 71.4 2 5 7 40 71.4 1.105 0006094 gluconeogenesis P 2 5 7 40 71.4 2 5 7 40 71.4 1.105 0006957 complement activation, alternative pathway P 2 5 7 40 71.4 2 5 7 40 71.4 1.105 0006093 anabolic carbohydrate metabolism P 0 0 0 0 0 2 5 7 40 71.4 1.105 0008443 phosphofructokinase F 0 0 0 0 0 2 5 5 40 100 1.105 0006582 melanin metabolism P 0 0 1 0 0 2 5 6 40 83.3 1.105 0008374 O-acyltransferase F 0 2 4 0 0 2 5 11 40 45.5 1.105 0015758 glucose transport P 2 5 6 40 83.3 2 5 6 40 83.3 1.105 0000314 organellar small ribosomal subunit C 0 0 0 0 0 2 5 7 40 71.4 1.105 0004016 adenylate cyclase F 2 5 7 40 71.4 2 5 7 40 71.4 1.105 0016529 sarcoplasmic reticulum C 2 5 5 40 100 2 5 5 40 100 1.105 0005351 sugar porter F 2 5 6 40 83.3 2 5 6 40 83.3 1.105 0006497 fatty acid:protein modification P 0 0 0 0 0 2 5 6 40 83.3 1.105 0015935 small ribosomal subunit C 0 0 0 0 0 2 5 8 40 62.5 1.105 0004022 alcohol dehydrogenase F 0 1 1 0 0 2 5 6 40 83.3 1.105 0007015 actin filament organization P 2 5 8 40 62.5 2 5 8 40 62.5 1.105 0008645 hexose transport P 0 0 0 0 0 2 5 6 40 83.3 1.105 0009636 detoxification response P 0 1 1 0 0 2 5 7 40 71.4 1.105 0007243 protein kinase cascade P 3 6 6 50 100 6 20 33 30 60.6 1.097 0016042 lipid catabolism P 5 18 24 27.8 75 6 20 26 30 76.9 1.097 0003793 defense/immunity protein F 2 13 27 15.4 48.1 15 58 114 25.9 50.9 1.085 0006950 stress response P 1 6 13 16.7 46.2 32 134 236 23.9 56.8 1.083 0019217 regulation of fatty acid metabolism P 1 2 2 50 100 1 2 2 50 100 1.051 0005185 neurohypophyseal hormone F 1 2 2 50 100 1 2 2 50 100 1.051 0015986 ATP synthesis coupled proton transport P 1 2 2 50 100 1 2 2 50 100 1.051 0016652 oxidoreductase, acting on NADH or NADPH, NAD or NADP as acceptor F 0 0 0 0 0 1 2 2 50 100 1.051 0006720 isoprenoid metabolism P 0 0 0 0 0 1 2 2 50 100 1.051 0005537 mannose binding F 1 2 2 50 100 1 2 2 50 100 1.051 0005741 mitochondrial outer membrane C 1 2 9 50 22.2 1 2 9 50 22.2 1.051 0004461 lactose synthase F 1 2 2 50 100 1 2 2 50 100 1.051 0003870 5-aminolevulinate synthase F 1 2 2 50 100 1 2 2 50 100 1.051 0004768 stearoyl-CoA desaturase F 1 2 3 50 66.7 1 2 3 50 66.7 1.051 0006825 copper ion transport P 1 2 2 50 100 1 2 2 50 100 1.051 0004739 pyruvate dehydrogenase (lipoamide) F 1 2 2 50 100 1 2 2 50 100 1.051 0005375 copper ion transporter F 0 0 0 0 0 1 2 2 50 100 1.051 0015985 energy coupled proton transport, down the electrochemical gradient P 0 0 0 0 0 1 2 2 50 100 1.051 0005913 cell-cell adherens junction C 0 1 2 0 0 1 2 5 50 40 1.051 0008900 hydrogen/potassium-exchanging ATPase F 1 2 2 50 100 1 2 2 50 100 1.051 0015701 bicarbonate transport P 1 2 2 50 100 1 2 2 50 100 1.051 0004551 nucleotide pyrophosphatase F 1 2 2 50 100 1 2 2 50 100 1.051 0003845 11-beta-hydroxysteroid dehydrogenase F 1 2 2 50 100 1 2 2 50 100 1.051 0015103 inorganic anion transporter F 0 0 0 0 0 1 2 4 50 50 1.051 0005952 cAMP-dependent protein kinase C 1 2 2 50 100 1 2 2 50 100 1.051 0005956 casein kinase II C 1 2 2 50 100 1 2 2 50 100 1.051 0009331 glycerol-3-phosphate dehydrogenase C 1 2 2 50 100 1 2 2 50 100 1.051 0015485 cholesterol binding F 1 2 2 50 100 1 2 2 50 100 1.051 0016222 procollagen-proline,2-oxoglutarate-4-dioxygenase C 1 2 2 50 100 1 2 2 50 100 1.051 0015248 sterol transporter F 0 0 0 0 0 1 2 2 50 100 1.051 0008435 anticoagulant F 1 2 2 50 100 1 2 2 50 100 1.051 0004007 heavy metal-exporting ATPase F 0 0 0 0 0 1 2 2 50 100 1.051 0004008 copper-exporting ATPase F 1 2 2 50 100 1 2 2 50 100 1.051 0015223 vitamin/cofactor transporter F 0 0 0 0 0 1 2 5 50 40 1.051 0005206 heparin sulfate proteoglycan F 1 2 5 50 40 1 2 5 50 40 1.051 0008517 folate transporter F 1 2 3 50 66.7 1 2 3 50 66.7 1.051 0003822 MHC-interacting protein F 1 2 6 50 33.3 1 2 6 50 33.3 1.051 0016215 CoA desaturase F 0 0 0 0 0 1 2 3 50 66.7 1.051 0008285 negative control of cell proliferation P 1 2 5 50 40 1 2 5 50 40 1.051 0005532 mannose binding lectin F 1 2 2 50 100 1 2 2 50 100 1.051 0005889 hydrogen/potassium-exchanging ATPase C 1 2 2 50 100 1 2 2 50 100 1.051 0006817 phosphate transport P 1 2 2 50 100 1 2 2 50 100 1.051 0008171 O-methyltransferase F 1 1 1 100 100 1 2 3 50 66.7 1.051 0006725 aromatic compound metabolism P 1 2 2 50 100 1 2 2 50 100 1.051 0004331 fructose-2,6-bisphosphatase F 1 2 2 50 100 1 2 2 50 100 1.051 0042132 fructose-1,6-bisphosphatase F 1 2 2 50 100 1 2 2 50 100 1.051 0016462 pyrophosphatase F 0 0 0 0 0 1 2 3 50 66.7 1.051 0004237 membrane dipeptidase F 1 2 2 50 100 1 2 2 50 100 1.051 0017127 cholesterol transporter F 1 2 2 50 100 1 2 2 50 100 1.051 0004528 phosphodiesterase I F 1 2 2 50 100 1 2 2 50 100 1.051 0016351 drug susceptibility/resistance P 1 2 3 50 66.7 1 2 3 50 66.7 1.051 0004785 copper, zinc superoxide dismutase F 1 2 2 50 100 1 2 2 50 100 1.051 0019867 outer membrane C 0 0 0 0 0 1 2 9 50 22.2 1.051 0004630 phospholipase D F 1 2 2 50 100 1 2 2 50 100 1.051 0008536 RAN protein binding F 1 2 4 50 50 1 2 4 50 50 1.051 0006354 RNA elongation P 1 2 2 50 100 1 2 2 50 100 1.051 0004738 pyruvate dehydrogenase F 0 0 0 0 0 1 2 2 50 100 1.051 0001525 angiogenesis P 1 2 2 50 100 1 2 2 50 100 1.051 0003873 6-phosphofructo-2-kinase F 1 2 2 50 100 1 2 2 50 100 1.051 0004994 somatostatin receptor F 1 2 2 50 100 1 2 2 50 100 1.051 0008537 proteasome activator complex C 1 2 2 50 100 1 2 2 50 100 1.051 0007004 telomere maintenance P 1 2 3 50 66.7 1 2 3 50 66.7 1.051 0008538 proteasome activator F 1 2 2 50 100 1 2 2 50 100 1.051 0003756 protein disulfide isomerase F 1 2 2 50 100 1 2 2 50 100 1.051 0007369 gastrulation P 1 2 2 50 100 1 2 2 50 100 1.051 0008606 phosphorylase kinase, catalyst F 1 2 2 50 100 1 2 2 50 100 1.051 0004682 casein kinase II F 0 0 0 0 0 1 2 2 50 100 1.051 0004680 casein kinase F 0 0 0 0 0 1 2 2 50 100 1.051 0004062 aryl sulfotransferase F 1 2 2 50 100 1 2 2 50 100 1.051 0004499 dimethylaniline monooxygenase (N-oxide forming) F 1 2 3 50 66.7 1 2 3 50 66.7 1.051 0006012 galactose metabolism P 1 2 2 50 100 1 2 2 50 100 1.051 0006072 glycerol-3-phosphate metabolism P 1 2 3 50 66.7 1 2 3 50 66.7 1.051 0000062 acyl-CoA binding F 1 2 3 50 66.7 1 2 3 50 66.7 1.051 0008610 lipid biosynthesis P 0 0 0 0 0 1 2 4 50 50 1.051 0001568 blood vessel development P 0 0 0 0 0 1 2 2 50 100 1.051 0004743 pyruvate kinase F 1 2 2 50 100 1 2 2 50 100 1.051 0006986 unfolded protein response P 1 2 2 50 100 1 2 2 50 100 1.051 0000228 nuclear chromosome C 1 2 4 50 50 1 2 4 50 50 1.051 0004887 thyroid hormone receptor F 1 2 2 50 100 1 2 2 50 100 1.051 0016211 ammonia ligase F 0 1 1 0 0 1 2 2 50 100 1.051 0016880 acid-ammonia (or amide) ligase F 0 0 0 0 0 1 2 2 50 100 1.051 0004019 adenylosuccinate synthase F 1 2 2 50 100 1 2 2 50 100 1.051 0004467 long-chain-fatty-acid-CoA-ligase F 1 2 2 50 100 1 2 2 50 100 1.051 0015645 fatty-acid ligase F 0 0 0 0 0 1 2 2 50 100 1.051 0016634 oxidoreductase, acting on the CH-CH group of donors, oxygen as acceptor F 0 0 0 0 0 1 2 5 50 40 1.051 0006446 translational regulation, initiation P 1 2 2 50 100 1 2 2 50 100 1.051 0008227 amine receptor F 0 0 0 0 0 1 2 3 50 66.7 1.051 0004921 interleukin-11 receptor F 1 2 2 50 100 1 2 2 50 100 1.051 0015833 peptide transport P 0 0 0 0 0 1 2 3 50 66.7 1.051 0016866 intramolecular transferase F 0 0 0 0 0 1 2 3 50 66.7 1.051 0005541 acyl-CoA or acyl binding F 0 0 0 0 0 1 2 3 50 66.7 1.051 0006857 oligopeptide transport P 1 2 3 50 66.7 1 2 3 50 66.7 1.051 0008073 ornithine decarboxylase inhibitor F 1 2 3 50 66.7 1 2 3 50 66.7 1.051 0008067 metabotropic glutamate, GABA-B-like receptor F 1 2 4 50 50 1 2 6 50 33.3 1.051 0019970 interleukin-11 binding F 0 0 0 0 0 1 2 2 50 100 1.051 0005623 cell C 0 0 0 0 0 594 2876 4096 20.7 70.2 1.04 0016746 transferase, transferring acyl groups F 0 0 0 0 0 9 33 43 27.3 76.7 1.019 0009605 response to external stimulus P 0 0 1 0 0 80 360 602 22.2 59.8 1.006 0005189 milk protein F 3 9 9 33.3 100 3 9 9 33.3 100 0.984 0007519 myogenesis P 3 7 7 42.9 100 3 9 12 33.3 75 0.984 0008076 voltage-gated potassium channel C 3 9 12 33.3 75 3 9 12 33.3 75 0.984 0006366 transcription, from Pol II promoter P 2 6 11 33.3 54.5 7 25 50 28 50 0.977 0009410 xenobiotic response P 0 0 0 0 0 7 25 43 28 58.1 0.977 0008289 lipid binding F 7 28 33 25 84.8 11 42 51 26.2 82.4 0.975 0015674 di-, tri-valent inorganic cation transport P 0 0 0 0 0 6 21 28 28.6 75 0.96 0007187 G-protein signaling, coupled to cyclic nucleotide second messenger P 0 0 0 0 0 6 21 27 28.6 77.8 0.96 0005249 voltage-sensitive potassium channel F 3 10 12 30 83.3 6 21 25 28.6 84 0.96 0015934 large ribosomal subunit C 0 0 0 0 0 4 13 16 30.8 81.2 0.953 0005762 mitochondrial large ribosomal subunit C 4 13 16 30.8 81.2 4 13 16 30.8 81.2 0.953 0007608 olfaction P 4 13 64 30.8 20.3 4 13 64 30.8 20.3 0.953 0000315 organellar large ribosomal subunit C 0 0 0 0 0 4 13 16 30.8 81.2 0.953 0005506 iron binding F 3 10 12 30 83.3 4 13 17 30.8 76.5 0.953 0005871 kinesin C 5 17 38 29.4 44.7 5 17 38 29.4 44.7 0.95 0004896 hematopoeitin/interferon-class (D200-domain) cytokine receptor F 8 28 29 28.6 96.6 10 38 42 26.3 90.5 0.946 0006612 protein-membrane targeting P 0 0 0 0 0 12 47 56 25.5 83.9 0.919 0006620 post-translational membrane targeting P 12 47 55 25.5 85.5 12 47 55 25.5 85.5 0.919 0008151 cell growth and/or maintenance P 28 140 162 20 86.4 538 2606 3511 20.6 74.2 0.902 0009613 response to pest/pathogen/parasite P 0 0 1 0 0 23 97 179 23.7 54.2 0.876 0005886 plasma membrane C 36 162 242 22.2 66.9 106 489 775 21.7 63.1 0.873 0009628 response to abiotic stimulus P 0 0 0 0 0 19 79 192 24.1 41.1 0.865 0005201 extracellular matrix structural constituent F 11 35 38 31.4 92.1 12 48 54 25 88.9 0.836 0003777 microtubule motor F 6 21 40 28.6 52.5 6 22 44 27.3 50 0.831 0015933 flavin-containing electron transporter F 0 0 0 0 0 5 18 22 27.8 81.8 0.805 0005753 proton-transporting ATP synthase complex C 2 6 9 33.3 66.7 2 6 9 33.3 66.7 0.803 0006220 pyrimidine nucleotide metabolism P 0 0 0 0 0 2 6 7 33.3 85.7 0.803 0009126 purine nucleoside monophosphate metabolism P 0 0 0 0 0 2 6 8 33.3 75 0.803 0004383 guanylate cyclase F 2 6 6 33.3 100 2 6 6 33.3 100 0.803 0015035 protein disulfide oxidoreductase F 2 6 6 33.3 100 2 6 6 33.3 100 0.803 0004437 inositol/phosphatidylinositol phosphatase F 2 4 5 50 80 2 6 9 33.3 66.7 0.803 0007190 adenylate cyclase activation P 2 6 8 33.3 75 2 6 8 33.3 75 0.803 0008016 control of heart P 2 6 6 33.3 100 2 6 6 33.3 100 0.803 0006833 water transport P 2 6 9 33.3 66.7 2 6 9 33.3 66.7 0.803 0015250 water channel F 2 6 9 33.3 66.7 2 6 9 33.3 66.7 0.803 0009129 pyrimidine nucleoside monophosphate metabolism P 0 0 0 0 0 2 6 7 33.3 85.7 0.803 0042044 fluid transport P 0 0 0 0 0 2 6 9 33.3 66.7 0.803 0005884 actin filament C 2 6 7 33.3 85.7 2 6 7 33.3 85.7 0.803 0006471 protein amino acid ADP-ribosylation P 2 6 6 33.3 100 2 6 6 33.3 100 0.803 0006417 general regulation of protein biosynthesis P 2 6 6 33.3 100 2 6 6 33.3 100 0.803 0005813 centrosome C 2 5 6 40 83.3 2 6 7 33.3 85.7 0.803 0008360 cell shape control P 2 6 8 33.3 75 2 6 8 33.3 75 0.803 0019206 nucleoside kinase F 0 0 0 0 0 2 6 6 33.3 100 0.803 0016831 carboxy-lyase F 0 2 3 0 0 2 6 10 33.3 60 0.803 0007193 G-protein signaling, adenylate cyclase inhibiting pathway P 2 6 6 33.3 100 2 6 6 33.3 100 0.803 0003774 motor F 11 40 64 27.5 62.5 11 44 72 25 61.1 0.801 0005764 lysosome C 11 41 53 26.8 77.4 11 44 57 25 77.2 0.801 0006810 transport P 35 159 193 22 82.4 101 468 627 21.6 74.6 0.797 0016818 hydrolase, acting on acid anhydrides, in phosphorus-containing anhydrides F 0 0 0 0 0 36 159 217 22.6 73.3 0.787 0016817 hydrolase, acting on acid anhydrides F 0 0 0 0 0 36 159 217 22.6 73.3 0.787 0006816 calcium ion transport P 4 14 18 28.6 77.8 4 14 18 28.6 77.8 0.784 0009593 perception of chemical substance P 0 0 0 0 0 4 14 90 28.6 15.6 0.784 0007606 chemosensory perception P 0 0 24 0 0 4 14 90 28.6 15.6 0.784 0016836 hydro-lyase F 0 1 1 0 0 4 14 21 28.6 66.7 0.784 0007189 G-protein signaling, adenylate cyclase activating pathway P 2 6 8 33.3 75 4 14 19 28.6 73.7 0.784 0008757 S-adenosylmethionine-dependent methyltransferase F 1 3 4 33.3 75 3 10 12 30 83.3 0.775 0006164 purine nucleotide biosynthesis P 1 6 8 16.7 75 3 10 13 30 76.9 0.775 0005544 calcium-dependent phospholipid binding F 3 10 11 30 90.9 3 10 11 30 90.9 0.775 0005865 striated muscle thin filament C 0 1 3 0 0 3 10 13 30 76.9 0.775 0006576 biogenic amine metabolism P 0 0 0 0 0 3 10 15 30 66.7 0.775 0006814 sodium transport P 3 10 16 30 62.5 3 10 16 30 62.5 0.775 0009607 response to biotic stimulus P 0 0 0 0 0 63 288 428 21.9 67.3 0.741 0006605 protein targeting P 1 4 6 25 66.7 15 63 75 23.8 84 0.723 0006955 immune response P 19 95 118 20 80.5 38 170 268 22.4 63.4 0.72 0006519 amino acid and derivative metabolism P 0 0 0 0 0 11 45 58 24.4 77.6 0.716 0005216 ion channel F 25 112 148 22.3 75.7 29 128 174 22.7 73.6 0.708 0006952 defense response P 30 131 172 22.9 76.2 61 280 414 21.8 67.6 0.691 0009581 perception of external stimulus P 0 0 0 0 0 19 82 197 23.2 41.6 0.681 0005244 voltage-gated ion channel F 9 39 55 23.1 70.9 10 41 57 24.4 71.9 0.675 0001501 skeletal development P 5 20 22 25 90.9 10 41 47 24.4 87.2 0.675 0015268 alpha-type channel F 0 0 0 0 0 33 148 200 22.3 74 0.653 0015267 channel/pore class transporter F 0 0 0 0 0 33 148 200 22.3 74 0.653 0016887 ATPase F 0 2 5 0 0 18 78 114 23.1 68.4 0.643 0015629 actin cytoskeleton C 4 17 23 23.5 73.9 11 46 63 23.9 73 0.634 0005834 heterotrimeric G-protein complex C 4 15 21 26.7 71.4 4 15 21 26.7 71.4 0.627 0000263 heterotrimeric G-protein GTPase, alpha-subunit F 4 15 16 26.7 93.8 4 15 16 26.7 93.8 0.627 0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway P 4 15 20 26.7 75 4 15 20 26.7 75 0.627 0003773 heat shock protein F 4 15 18 26.7 83.3 4 15 18 26.7 83.3 0.627 0016835 carbon-oxygen lyase F 0 0 0 0 0 4 15 23 26.7 65.2 0.627 0003795 antimicrobial peptide F 2 9 22 22.2 40.9 3 11 24 27.3 45.8 0.587 0030016 myofibril C 0 0 0 0 0 3 11 15 27.3 73.3 0.587 0030017 sarcomere C 0 0 0 0 0 3 11 15 27.3 73.3 0.587 0030484 muscle fiber C 0 0 0 0 0 3 11 16 27.3 68.8 0.587 0008235 metalloexopeptidase F 0 3 3 0 0 3 11 12 27.3 91.7 0.587 0015442 hydrogen-/sodium-translocating ATPase F 0 0 0 0 0 3 11 16 27.3 68.8 0.587 0003936 hydrogen-transporting two-sector ATPase F 2 10 14 20 71.4 3 11 16 27.3 68.8 0.587 0005242 inward rectifier potassium channel F 3 11 13 27.3 84.6 3 11 13 27.3 84.6 0.587 0007601 vision P 3 10 13 30 76.9 3 11 14 27.3 78.6 0.587 0006112 metabolism of energy reserves P 1 2 2 50 100 3 11 16 27.3 68.8 0.587 0001558 regulation of cell growth P 3 10 14 30 71.4 3 11 15 27.3 73.3 0.587 0019200 carbohydrate kinase F 0 0 0 0 0 3 11 11 27.3 100 0.587 0006826 iron transport P 1 3 6 33.3 50 1 3 6 33.3 50 0.568 0005542 folate binding F 1 3 4 33.3 75 1 3 4 33.3 75 0.568 0000002 mitochondrial genome maintenance P 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0008637 apoptotic mitochondrial changes P 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0004859 phospholipase inhibitor F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0015301 anion:anion antiporter F 0 0 0 0 0 1 3 4 33.3 75 0.568 0008484 sulfuric ester hydrolase F 1 3 5 33.3 60 1 3 5 33.3 60 0.568 0006584 catecholamine metabolism P 1 3 6 33.3 50 1 3 6 33.3 50 0.568 0005035 death receptor F 0 0 1 0 0 1 3 8 33.3 37.5 0.568 0005890 sodium/potassium-exchanging ATPase C 1 3 4 33.3 75 1 3 4 33.3 75 0.568 0016160 amylase F 0 0 0 0 0 1 3 3 33.3 100 0.568 0007259 JAK-STAT cascade P 1 3 5 33.3 60 1 3 6 33.3 50 0.568 0005031 tumor necrosis factor receptor F 1 3 5 33.3 60 1 3 5 33.3 60 0.568 0006570 tyrosine metabolism P 0 0 0 0 0 1 3 4 33.3 75 0.568 0004931 ATP-gated cation channel F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0005452 inorganic anion exchanger F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0016805 dipeptidase F 0 0 0 0 0 1 3 3 33.3 100 0.568 0008239 dipeptidyl-peptidase F 1 1 1 100 100 1 3 3 33.3 100 0.568 0005638 lamin filament C 1 3 4 33.3 75 1 3 4 33.3 75 0.568 0004459 L-lactate dehydrogenase F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0016408 C-acyltransferase F 0 0 0 0 0 1 3 3 33.3 100 0.568 0003950 NAD(+) ADP-ribosyltransferase F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0004556 alpha-amylase F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0017085 insecticide response P 0 0 0 0 0 1 3 3 33.3 100 0.568 0003953 NAD(+) nucleosidase F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0005637 nuclear inner membrane C 0 0 0 0 0 1 3 4 33.3 75 0.568 0006650 glycerophospholipid metabolism P 0 1 1 0 0 1 3 5 33.3 60 0.568 0005172 vascular endothelial growth factor receptor ligand F 1 3 4 33.3 75 1 3 4 33.3 75 0.568 0016591 DNA-directed RNA polymerase II, holoenzyme C 0 0 0 0 0 1 3 4 33.3 75 0.568 0030120 vesicle coat C 0 0 0 0 0 1 3 6 33.3 50 0.568 0006445 translational regulation P 0 1 2 0 0 1 3 4 33.3 75 0.568 0015380 anion exchanger F 0 0 1 0 0 1 3 4 33.3 75 0.568 0015992 proton transport P 0 0 0 0 0 1 3 5 33.3 60 0.568 0016356 organophosphosphorous susceptibility/resistance P 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0004035 alkaline phosphatase F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0008199 ferric iron binding F 1 3 5 33.3 60 1 3 5 33.3 60 0.568 0005027 NGF/TNF (6 C-domain) receptor F 0 0 0 0 0 1 3 5 33.3 60 0.568 0007286 spermatid development P 1 3 4 33.3 75 1 3 5 33.3 60 0.568 0007611 learning and memory P 1 1 1 100 100 1 3 4 33.3 75 0.568 0004457 lactate dehydrogenase F 0 0 0 0 0 1 3 3 33.3 100 0.568 0019221 cytokine and chemokine mediated signaling pathway P 1 3 7 33.3 42.9 1 3 7 33.3 42.9 0.568 0008158 patched receptor F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0016409 palmitoyltransferase F 0 0 0 0 0 1 3 4 33.3 75 0.568 0005698 centromere C 1 3 4 33.3 75 1 3 4 33.3 75 0.568 0006020 myo-inositol metabolism P 1 3 4 33.3 75 1 3 4 33.3 75 0.568 0003767 cochaperone F 1 2 2 50 100 1 3 3 33.3 100 0.568 0016352 insecticide susceptibility/resistance P 0 0 0 0 0 1 3 3 33.3 100 0.568 0005224 ATP-binding and phosphorylation-dependent chloride channel F 1 3 4 33.3 75 1 3 4 33.3 75 0.568 0005217 intracellular ligand-gated ion channel F 0 0 0 0 0 1 3 4 33.3 75 0.568 0016865 intramolecular isomerase, other intramolecular oxidoreductases F 0 0 0 0 0 1 3 4 33.3 75 0.568 0002009 morphogenesis of an epithelium P 1 3 4 33.3 75 1 3 4 33.3 75 0.568 0016714 oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen F 0 0 0 0 0 1 3 3 33.3 100 0.568 0006572 tyrosine catabolism P 1 3 4 33.3 75 1 3 4 33.3 75 0.568 0007032 endosome organization and biogenesis P 0 0 0 0 0 1 3 3 33.3 100 0.568 0016197 endosome transport P 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0030125 clathrin vesicle coat C 1 3 6 33.3 50 1 3 6 33.3 50 0.568 0005696 telomere C 0 2 3 0 0 1 3 4 33.3 75 0.568 0005945 6-phosphofructokinase C 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0003872 6-phosphofructokinase F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0005522 profilin binding F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0004064 arylesterase F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0003847 2-acetyl-1-alkylglycerophosphocholine esterase F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0001614 purinergic nucleotide receptor F 0 0 0 0 0 1 3 3 33.3 100 0.568 0005080 protein kinase C binding F 1 3 3 33.3 100 1 3 3 33.3 100 0.568 0005247 voltage-gated chloride channel F 1 3 8 33.3 37.5 1 3 8 33.3 37.5 0.568 0019239 deaminase F 0 0 0 0 0 1 3 6 33.3 50 0.568 0005815 microtubule organizing center C 0 0 0 0 0 2 7 8 28.6 87.5 0.554 0006753 nucleoside phosphate metabolism P 0 0 0 0 0 2 7 11 28.6 63.6 0.554 0004293 tissue kallikrein F 2 7 12 28.6 58.3 2 7 12 28.6 58.3 0.554 0015076 heavy metal ion transporter F 0 0 1 0 0 2 7 9 28.6 77.8 0.554 0005373 heavy metal ion porter F 0 0 0 0 0 2 7 8 28.6 87.5 0.554 0000041 transition metal transport P 0 0 0 0 0 2 7 10 28.6 70 0.554 0004892 B-cell receptor F 0 0 0 0 0 2 7 44 28.6 15.9 0.554 0016849 phosphorus-oxygen lyase F 0 0 0 0 0 2 7 9 28.6 77.8 0.554 0003823 antibody F 2 7 44 28.6 15.9 2 7 44 28.6 15.9 0.554 0005211 plasma glycoprotein F 2 7 7 28.6 100 2 7 7 28.6 100 0.554 0015082 di-, tri-valent inorganic cation transporter F 0 0 0 0 0 2 7 8 28.6 87.5 0.554 0007411 axon guidance P 2 6 10 33.3 60 2 7 11 28.6 63.6 0.554 0007148 cell shape and cell size control P 0 2 2 0 0 2 7 9 28.6 77.8 0.554 0004407 histone deacetylase F 2 6 9 33.3 66.7 2 7 10 28.6 70 0.554 0008037 cell recognition P 0 0 0 0 0 2 7 11 28.6 63.6 0.554 0006754 ATP biosynthesis P 2 7 11 28.6 63.6 2 7 11 28.6 63.6 0.554 0005076 receptor signaling protein serine/threonine kinase signaling protein F 0 0 0 0 0 2 7 10 28.6 70 0.554 0006633 fatty acid biosynthesis P 2 6 9 33.3 66.7 2 7 11 28.6 63.6 0.554 0003743 translation initiation factor F 2 7 10 28.6 70 2 7 10 28.6 70 0.554 0007200 G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) P 0 3 5 0 0 2 7 13 28.6 53.8 0.554 0019936 inositol phospholipid-mediated signaling P 0 0 1 0 0 2 7 14 28.6 50 0.554 0004707 MAP kinase F 2 7 9 28.6 77.8 2 7 9 28.6 77.8 0.554 0015144 carbohydrate transporter F 0 0 0 0 0 2 7 9 28.6 77.8 0.554 0004198 calpain F 2 7 8 28.6 87.5 2 7 8 28.6 87.5 0.554 0008080 N-acetyltransferase F 2 3 4 66.7 75 2 7 8 28.6 87.5 0.554 0009190 cyclic nucleotide biosynthesis P 0 0 0 0 0 2 7 9 28.6 77.8 0.554 0008483 transaminase F 1 4 4 25 100 2 7 9 28.6 77.8 0.554 0006413 protein synthesis initiation P 2 7 10 28.6 70 2 7 10 28.6 70 0.554 0005160 transforming growth factor-beta receptor ligand F 2 4 4 50 100 2 7 7 28.6 100 0.554 0009187 cyclic nucleotide metabolism P 0 0 0 0 0 2 7 9 28.6 77.8 0.554 0016769 transferase, transferring nitrogenous groups F 0 0 0 0 0 2 7 9 28.6 77.8 0.554 0009072 aromatic amino acid family metabolism P 1 3 3 33.3 100 2 7 8 28.6 87.5 0.554 0005319 lipid transporter F 5 16 21 31.2 76.2 5 20 27 25 74.1 0.538 0016874 ligase F 0 0 0 0 0 7 29 40 24.1 72.5 0.533 0006732 coenzyme metabolism P 0 0 0 0 0 4 16 22 25 72.7 0.481 0008009 chemokine F 6 25 32 24 78.1 6 25 32 24 78.1 0.477 0012505 endomembrane system C 0 0 0 0 0 109 520 819 21 63.5 0.472 0008270 zinc binding F 7 30 40 23.3 75 7 30 40 23.3 75 0.432 0004222 metalloendopeptidase F 9 40 55 22.5 72.7 10 44 61 22.7 72.1 0.423 0007050 cell cycle arrest P 3 12 12 25 100 3 12 12 25 100 0.417 0006913 nucleocytoplasmic transport P 1 3 6 33.3 50 3 12 17 25 70.6 0.417 0006163 purine nucleotide metabolism P 0 0 0 0 0 3 12 16 25 75 0.417 0007423 sensory organ development P 3 12 17 25 70.6 3 12 17 25 70.6 0.417 0006818 hydrogen transport P 2 9 12 22.2 75 3 12 17 25 70.6 0.417 0016859 cis-trans isomerase F 0 0 0 0 0 3 12 16 25 75 0.417 0016482 cytoplasmic transport P 0 0 0 0 0 3 12 17 25 70.6 0.417 0003755 peptidylprolyl cis-trans isomerase F 3 12 16 25 75 3 12 16 25 75 0.417 0004907 interleukin receptor F 5 20 24 25 83.3 5 21 25 23.8 84 0.415 0019965 interleukin binding F 0 0 0 0 0 5 21 25 23.8 84 0.415 0006805 xenobiotic metabolism P 4 18 33 22.2 54.5 5 21 36 23.8 58.3 0.415 0005200 structural constituent of cytoskeleton F 14 63 79 22.2 79.7 14 63 79 22.2 79.7 0.407 0007028 cytoplasm organization and biogenesis P 1 1 2 100 50 36 169 241 21.3 70.1 0.37 0009117 nucleotide metabolism P 1 3 3 33.3 100 6 26 35 23.1 74.3 0.369 0005262 calcium channel F 4 17 26 23.5 65.4 4 17 26 23.5 65.4 0.345 0003928 RAB small monomeric GTPase F 4 17 23 23.5 73.9 4 17 23 23.5 73.9 0.345 0004175 endopeptidase F 1 4 5 25 80 10 45 63 22.2 71.4 0.343 0006823 heavy metal ion transport P 1 3 4 33.3 75 2 8 12 25 66.7 0.34 0004114 3’,5’-cyclic-nucleotide phosphodiesterase F 2 8 13 25 61.5 2 8 18 25 44.4 0.34 0007409 axonogenesis P 0 1 6 0 0 2 8 17 25 47.1 0.34 0016459 myosin C 2 8 11 25 72.7 2 8 12 25 66.7 0.34 0016563 transcriptional activator F 2 8 13 25 61.5 2 8 13 25 61.5 0.34 0016782 transferase, transferring sulfur-containing groups F 0 0 0 0 0 2 8 16 25 50 0.34 0008146 sulfotransferase F 2 6 10 33.3 60 2 8 14 25 57.1 0.34 0005525 GTP binding F 24 123 175 19.5 70.3 30 141 201 21.3 70.1 0.33 0007010 cytoskeleton organization and biogenesis P 9 53 73 17 72.6 25 117 175 21.4 66.9 0.324 0004867 serine protease inhibitor F 10 45 56 22.2 80.4 11 50 65 22 76.9 0.323 0007345 embryogenesis and morphogenesis P 5 34 46 14.7 73.9 55 263 349 20.9 75.4 0.305 0007397 histogenesis and organogenesis P 12 90 110 13.3 81.8 48 229 301 21 76.1 0.302 0006951 heat shock response P 5 22 31 22.7 71 5 22 31 22.7 71 0.298 0009266 temperature response P 0 0 0 0 0 5 22 31 22.7 71 0.298 0005575 cellular_component C 0 0 0 0 0 657 3238 4691 20.3 69 0.291 0003927 heterotrimeric G-protein GTPase F 2 12 18 16.7 66.7 6 27 35 22.2 77.1 0.265 0016023 cytoplasmic vesicle C 3 5 9 60 55.6 6 27 45 22.2 60 0.265 0016298 lipase F 0 1 1 0 0 3 13 17 23.1 76.5 0.261 0005543 phospholipid binding F 0 1 2 0 0 3 13 18 23.1 72.2 0.261 0005212 structural constituent of eye lens F 3 13 19 23.1 68.4 3 13 19 23.1 68.4 0.261 0005941 unlocalized C 0 0 0 0 0 11 51 58 21.6 87.9 0.249 0007600 sensory perception P 0 2 4 0 0 7 32 116 21.9 27.6 0.24 0009582 perception of abiotic stimulus P 0 0 0 0 0 7 32 117 21.9 27.4 0.24 0009566 fertilization P 0 0 0 0 0 1 4 5 25 80 0.24 0007338 fertilization (sensu Animalia) P 0 2 2 0 0 1 4 5 25 80 0.24 0008376 acetylgalactosaminyltransferase F 0 0 0 0 0 1 4 5 25 80 0.24 0042079 GPI/GSI anchor metabolism P 0 0 0 0 0 1 4 5 25 80 0.24 0006505 GPI anchor metabolism P 0 0 1 0 0 1 4 5 25 80 0.24 0004032 aldehyde reductase F 1 4 4 25 100 1 4 4 25 100 0.24 0005320 apolipoprotein F 1 4 5 25 80 1 4 6 25 66.7 0.24 0000165 MAPKKK cascade P 1 3 7 33.3 42.9 1 4 8 25 50 0.24 0006733 oxidoreduction coenzyme metabolism P 0 0 0 0 0 1 4 4 25 100 0.24 0004653 polypeptide N-acetylgalactosaminyltransferase F 1 4 4 25 100 1 4 4 25 100 0.24 0004060 arylamine N-acetyltransferase F 1 4 4 25 100 1 4 4 25 100 0.24 0007507 heart development P 1 4 6 25 66.7 1 4 6 25 66.7 0.24 0004303 estradiol 17 beta-dehydrogenase F 1 4 5 25 80 1 4 5 25 80 0.24 0004659 prenyltransferase F 1 2 2 50 100 1 4 4 25 100 0.24 0007222 frizzled receptor signaling pathway P 1 4 5 25 80 1 4 5 25 80 0.24 0005079 protein kinase A anchor protein F 1 4 6 25 66.7 1 4 6 25 66.7 0.24 0003964 RNA-directed DNA polymerase F 1 4 4 25 100 1 4 4 25 100 0.24 0016284 alanine aminopeptidase F 0 0 0 0 0 1 4 4 25 100 0.24 0006974 DNA damage response P 0 2 2 0 0 1 4 5 25 80 0.24 0005881 cytoplasmic microtubule C 0 0 0 0 0 1 4 5 25 80 0.24 0004602 glutathione peroxidase F 1 4 5 25 80 1 4 5 25 80 0.24 0019136 deoxynucleoside kinase F 0 0 0 0 0 1 4 4 25 100 0.24 0030117 membrane coat C 0 0 0 0 0 1 4 7 25 57.1 0.24 0004396 hexokinase F 1 4 4 25 100 1 4 4 25 100 0.24 0005868 cytoplasmic dynein C 1 4 5 25 80 1 4 5 25 80 0.24 0004179 membrane alanyl aminopeptidase F 1 4 4 25 100 1 4 4 25 100 0.24 0004194 pepsin A F 1 4 6 25 66.7 1 4 6 25 66.7 0.24 0005786 signal recognition particle C 1 4 5 25 80 1 4 5 25 80 0.24 0003794 acute-phase response protein F 1 4 4 25 100 1 4 4 25 100 0.24 0015023 syndecan F 1 4 4 25 100 1 4 4 25 100 0.24 0016469 hydrogen-transporting two-sector ATPase C 1 3 4 33.3 75 1 4 6 25 66.7 0.24 0030118 clathrin coat C 0 0 0 0 0 1 4 7 25 57.1 0.24 0005891 voltage-gated calcium channel C 1 4 6 25 66.7 1 4 6 25 66.7 0.24 0003686 DNA repair enzyme F 1 3 4 33.3 75 1 4 5 25 80 0.24 0005515 protein binding F 32 183 275 17.5 66.5 76 368 539 20.7 68.3 0.236 0008369 obsolete F 0 0 0 0 0 32 153 201 20.9 76.1 0.231 0008152 metabolism P 34 89 102 38.2 87.3 364 1789 2348 20.3 76.2 0.226 0005496 steroid binding F 1 14 16 7.1 87.5 4 18 20 22.2 90 0.216 0019898 extrinsic membrane protein C 0 0 0 0 0 4 18 26 22.2 69.2 0.216 0019897 extrinsic plasma membrane protein C 0 3 5 0 0 4 18 26 22.2 69.2 0.216 0005208 amyloid protein F 2 9 9 22.2 100 2 9 9 22.2 100 0.153 0004620 phospholipase F 0 1 1 0 0 2 9 13 22.2 69.2 0.153 0006606 protein-nucleus import P 2 7 8 28.6 87.5 2 9 10 22.2 90 0.153 0016171 cell surface antigen F 2 9 11 22.2 81.8 2 9 11 22.2 81.8 0.153 0009165 nucleotide biosynthesis P 0 2 3 0 0 2 9 13 22.2 69.2 0.153 0004112 cyclic-nucleotide phosphodiesterase F 0 0 0 0 0 2 9 19 22.2 47.4 0.153 0006752 group transfer coenzyme metabolism P 0 0 0 0 0 2 9 14 22.2 64.3 0.153 0007266 RHO protein signal transduction P 2 9 11 22.2 81.8 2 9 11 22.2 81.8 0.153 0005977 glycogen metabolism P 2 6 10 33.3 60 2 9 14 22.2 64.3 0.153 0004197 cysteine-type endopeptidase F 5 18 24 27.8 75 7 33 41 21.2 80.5 0.148 0019001 guanyl nucleotide binding F 0 0 0 0 0 32 155 219 20.6 70.8 0.147 0006643 membrane lipid metabolism P 0 0 0 0 0 3 14 19 21.4 73.7 0.117 0006644 phospholipid metabolism P 2 4 4 50 100 3 14 19 21.4 73.7 0.117 0003779 actin binding F 11 57 78 19.3 73.1 12 58 83 20.7 69.9 0.097 0005839 20S core proteasome C 3 17 17 17.6 100 4 19 19 21.1 100 0.095 0003712 transcription co-factor F 1 5 8 20 62.5 5 24 39 20.8 61.5 0.08 0007283 spermatogenesis P 4 21 29 19 72.4 5 24 34 20.8 70.6 0.08 0003924 GTPase F 4 18 21 22.2 85.7 16 78 95 20.5 82.1 0.074 0016302 phosphatase F 1 5 5 20 100 17 83 108 20.5 76.9 0.069 0016773 phosphotransferase, alcohol group as acceptor F 0 0 0 0 0 62 305 386 20.3 79 0.067 0007275 developmental processes P 15 80 98 18.8 81.6 72 355 471 20.3 75.4 0.05 0016043 cell organization and biogenesis P 0 0 0 0 0 42 207 294 20.3 70.4 0.041 0004857 enzyme inhibitor F 1 2 3 50 66.7 17 84 108 20.2 77.8 0.014 0005509 calcium binding F 39 194 266 20.1 72.9 40 198 271 20.2 73.1 0.008 GO Gene Ontology r 0 0 0 0 0 923 4574 6697 20.2 68.3 0 0005198 structural molecule F 9 36 47 25 76.6 45 223 278 20.2 80.2 0 0000074 cell cycle control P 22 111 132 19.8 84.1 25 124 146 20.2 84.9 -0.005 0005507 copper binding F 1 5 10 20 50 1 5 10 20 50 -0.01 0006767 water-soluble vitamin metabolism P 0 0 0 0 0 1 5 5 20 100 -0.01 0005381 iron transporter F 1 5 6 20 83.3 1 5 6 20 83.3 -0.01 0015297 antiporter F 0 0 0 0 0 1 5 8 20 62.5 -0.01 0004180 carboxypeptidase F 1 5 8 20 62.5 1 5 8 20 62.5 -0.01 0004212 lysosomal cysteine-type endopeptidase F 0 0 0 0 0 1 5 7 20 71.4 -0.01 0016814 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines F 1 2 2 50 100 1 5 9 20 55.6 -0.01 0000082 G1/S transition of mitotic cell cycle P 1 3 5 33.3 60 1 5 7 20 71.4 -0.01 0005245 voltage-sensitive calcium channel F 1 5 6 20 83.3 1 5 7 20 71.4 -0.01 0016863 intramolecular isomerase, transposing C=C bonds F 0 0 0 0 0 1 5 5 20 100 -0.01 0007249 NIK-I-kappaB/NF-kappaB cascade P 1 3 6 33.3 50 1 5 8 20 62.5 -0.01 0005514 calcium storage F 1 5 5 20 100 1 5 5 20 100 -0.01 0004623 phospholipase A2 F 1 5 6 20 83.3 1 5 6 20 83.3 -0.01 0006885 pH regulation P 1 4 5 25 80 1 5 6 20 83.3 -0.01 0005558 minor histocompatibility antigen F 1 5 7 20 71.4 1 5 7 20 71.4 -0.01 0003782 F-actin capping F 1 5 8 20 62.5 1 5 8 20 62.5 -0.01 0016883 other carbon-nitrogen ligase F 0 0 0 0 0 1 5 5 20 100 -0.01 0007492 endoderm development P 0 3 7 0 0 1 5 9 20 55.6 -0.01 0008290 actin capping protein C 1 5 7 20 71.4 1 5 7 20 71.4 -0.01 0030004 monovalent inorganic cation homeostasis P 0 0 0 0 0 1 5 7 20 71.4 -0.01 0003828 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase F 1 5 5 20 100 1 5 5 20 100 -0.01 0004926 non-G-protein coupled 7TM receptor F 0 0 0 0 0 2 10 12 20 83.3 -0.014 0005976 polysaccharide metabolism P 0 0 0 0 0 2 10 15 20 66.7 -0.014 0016410 N-acyltransferase F 0 1 1 0 0 2 10 11 20 90.9 -0.014 0003899 DNA-directed RNA polymerase F 2 10 11 20 90.9 2 10 11 20 90.9 -0.014 0008509 anion transporter F 0 0 1 0 0 2 10 16 20 62.5 -0.014 0004984 olfactory receptor F 2 10 61 20 16.4 2 10 61 20 16.4 -0.014 0004860 protein kinase inhibitor F 2 4 4 50 100 2 10 11 20 90.9 -0.014 0030097 hemopoiesis P 2 7 9 28.6 77.8 2 10 15 20 66.7 -0.014 0008643 carbohydrate transport P 2 7 8 28.6 87.5 2 10 12 20 83.3 -0.014 0009314 radiation response P 0 0 0 0 0 3 15 21 20 71.4 -0.017 0007422 peripheral nervous system development P 0 3 3 0 0 3 15 20 20 75 -0.017 0008238 exopeptidase F 0 0 0 0 0 3 15 18 20 83.3 -0.017 0006968 cellular defense response P 3 12 37 25 32.4 3 15 43 20 34.9 -0.017 0009416 light response P 0 0 0 0 0 3 15 21 20 71.4 -0.017 0009583 perception of light P 0 0 0 0 0 3 15 21 20 71.4 -0.017 0006731 coenzymes and prosthetic group metabolism P 0 0 0 0 0 6 30 40 20 75 -0.025 0000003 reproduction P 0 0 0 0 0 6 30 42 20 71.4 -0.025 0030414 protease inhibitor F 0 0 0 0 0 13 65 86 20 75.6 -0.036 0004866 endopeptidase inhibitor F 2 9 11 22.2 81.8 13 65 86 20 75.6 -0.036 0016740 transferase F 0 6 8 0 0 96 478 613 20.1 78 -0.055 0000267 cell fraction C 0 0 0 0 0 15 76 107 19.7 71 -0.097 0005624 membrane fraction C 7 30 48 23.3 62.5 15 76 106 19.7 71.7 -0.097 0005622 intracellular C 38 236 285 16.1 82.8 468 2326 3364 20.1 69.1 -0.101 0005516 calmodulin binding F 7 36 46 19.4 78.3 7 36 46 19.4 78.3 -0.11 0016301 kinase F 1 6 11 16.7 54.5 62 311 394 19.9 78.9 -0.111 0007276 gametogenesis P 0 1 2 0 0 5 26 37 19.2 70.3 -0.121 0001503 ossification P 4 19 20 21.1 95 4 21 24 19 87.5 -0.129 0008015 circulation P 0 1 1 0 0 3 16 17 18.8 94.1 -0.143 0005718 nucleosome C 2 11 18 18.2 61.1 2 11 18 18.2 61.1 -0.165 0016125 sterol metabolism P 0 0 0 0 0 2 11 14 18.2 78.6 -0.165 0005164 tumor necrosis factor receptor ligand F 2 11 13 18.2 84.6 2 11 13 18.2 84.6 -0.165 0008203 cholesterol metabolism P 1 5 6 20 83.3 2 11 14 18.2 78.6 -0.165 0019210 kinase inhibitor F 0 1 1 0 0 2 11 12 18.2 91.7 -0.165 0007417 central nervous system development P 1 6 8 16.7 75 2 11 15 18.2 73.3 -0.165 0016763 transferase, transferring pentosyl groups F 0 0 0 0 0 2 11 13 18.2 84.6 -0.165 0008237 metallopeptidase F 3 31 46 9.7 67.4 10 52 74 19.2 70.3 -0.171 0016788 hydrolase, acting on ester bonds F 0 3 3 0 0 32 163 239 19.6 68.2 -0.177 0004725 protein tyrosine phosphatase F 7 37 47 18.9 78.7 7 37 47 18.9 78.7 -0.192 0016265 death P 0 0 0 0 0 21 108 138 19.4 78.3 -0.193 0016791 phosphoric monoester hydrolase F 0 0 0 0 0 15 78 104 19.2 75 -0.211 0030141 secretory granule C 1 6 9 16.7 66.7 1 6 9 16.7 66.7 -0.215 0005978 glycogen biosynthesis P 1 6 7 16.7 85.7 1 6 7 16.7 85.7 -0.215 0000226 microtubule cytoskeleton organization and biogenesis P 1 2 2 50 100 1 6 7 16.7 85.7 -0.215 0016799 hydrolase, hydrolyzing N-glycosyl compounds F 0 0 0 0 0 1 6 6 16.7 100 -0.215 0007420 brain development P 1 6 8 16.7 75 1 6 8 16.7 75 -0.215 0006691 leukotriene metabolism P 1 6 8 16.7 75 1 6 8 16.7 75 -0.215 0005550 pheromone binding F 1 6 6 16.7 100 1 6 6 16.7 100 -0.215 0004190 aspartic-type endopeptidase F 1 6 10 16.7 60 1 6 10 16.7 60 -0.215 0030286 dynein C 0 0 0 0 0 1 6 8 16.7 75 -0.215 0006879 iron homeostasis P 1 6 11 16.7 54.5 1 6 11 16.7 54.5 -0.215 0001524 globin F 1 6 7 16.7 85.7 1 6 7 16.7 85.7 -0.215 0007005 mitochondrion organization and biogenesis P 0 0 1 0 0 1 6 7 16.7 85.7 -0.215 0008222 tumor antigen F 1 6 12 16.7 50 1 6 12 16.7 50 -0.215 0008533 astacin F 1 6 6 16.7 100 1 6 6 16.7 100 -0.215 0016709 oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen F 0 0 0 0 0 1 6 7 16.7 85.7 -0.215 0030006 heavy metal ion homeostasis P 0 0 0 0 0 1 6 11 16.7 54.5 -0.215 0008134 transcription factor binding F 0 2 3 0 0 5 27 43 18.5 62.8 -0.216 0005837 26S proteasome C 0 2 3 0 0 4 22 23 18.2 95.7 -0.234 0006457 protein folding P 4 22 31 18.2 71 4 22 31 18.2 71 -0.234 0015698 inorganic anion transport P 0 0 0 0 0 4 22 33 18.2 66.7 -0.234 0016311 dephosphorylation P 0 0 0 0 0 8 43 50 18.6 86 -0.258 0006470 protein amino acid dephosphorylation P 8 43 50 18.6 86 8 43 50 18.6 86 -0.258 0008168 methyltransferase F 1 3 3 33.3 100 3 17 27 17.6 63 -0.261 0005162 fibroblast growth factor receptor ligand F 3 17 18 17.6 94.4 3 17 18 17.6 94.4 -0.261 0005874 microtubule C 2 11 13 18.2 84.6 3 17 21 17.6 81 -0.261 0008234 cysteine-type peptidase F 5 30 47 16.7 63.8 7 38 57 18.4 66.7 -0.271 0030554 adenyl nucleotide binding F 0 0 0 0 0 91 462 663 19.7 69.7 -0.272 0005524 ATP binding F 86 446 635 19.3 70.2 91 462 663 19.7 69.7 -0.272 0006928 cell motility P 0 2 4 0 0 13 69 89 18.8 77.5 -0.279 0016772 transferase, transferring phosphorus-containing groups F 0 3 5 0 0 67 342 431 19.6 79.4 -0.282 0004674 protein serine/threonine kinase F 31 153 205 20.3 74.6 35 181 243 19.3 74.5 -0.288 0017076 purine nucleotide binding F 0 0 0 0 0 121 613 877 19.7 69.9 -0.292 0042175 nuclear envelope-endoplasmic reticulum network C 0 0 0 0 0 2 12 17 16.7 70.6 -0.304 0030029 actin filament-based process P 0 0 1 0 0 2 12 20 16.7 60 -0.304 0009653 morphogenesis P 0 3 3 0 0 2 12 15 16.7 80 -0.304 0030036 actin cytoskeleton organization and biogenesis P 0 6 10 0 0 2 12 19 16.7 63.2 -0.304 0003746 translation elongation factor F 2 12 16 16.7 75 2 12 16 16.7 75 -0.304 0005083 small GTPase regulatory/interacting protein F 4 10 18 40 55.6 10 54 78 18.5 69.2 -0.306 0000166 nucleotide binding F 6 21 26 28.6 80.8 121 614 878 19.7 69.9 -0.313 0004295 trypsin F 9 49 58 18.4 84.5 9 49 58 18.4 84.5 -0.318 0004263 chymotrypsin F 8 44 51 18.2 86.3 8 44 51 18.2 86.3 -0.332 0008150 biological_process P 0 0 0 0 0 711 3544 4962 20.1 71.4 -0.366 0004553 hydrolase, hydrolyzing O-glycosyl compounds F 1 3 5 33.3 60 3 18 26 16.7 69.2 -0.372 0016051 carbohydrate biosynthesis P 0 1 1 0 0 3 18 24 16.7 75 -0.372 0016879 ligase, forming carbon-nitrogen bonds F 0 0 0 0 0 3 18 24 16.7 75 -0.372 0015671 oxygen transport P 1 7 8 14.3 87.5 1 7 8 14.3 87.5 -0.389 0006695 cholesterol biosynthesis P 1 7 8 14.3 87.5 1 7 8 14.3 87.5 -0.389 0006665 sphingolipid metabolism P 0 3 3 0 0 1 7 9 14.3 77.8 -0.389 0015669 gas transport P 0 0 0 0 0 1 7 8 14.3 87.5 -0.389 0005344 oxygen transporter F 1 7 9 14.3 77.8 1 7 9 14.3 77.8 -0.389 0008378 galactosyltransferase F 0 1 2 0 0 1 7 11 14.3 63.6 -0.389 0015450 protein translocase F 1 7 7 14.3 100 1 7 7 14.3 100 -0.389 0007272 ionic insulation of neurons by glial cells P 1 7 9 14.3 77.8 1 7 9 14.3 77.8 -0.389 0004928 frizzled receptor F 1 7 9 14.3 77.8 1 7 9 14.3 77.8 -0.389 0007626 locomotory behavior P 1 4 6 25 66.7 1 7 9 14.3 77.8 -0.389 0006692 prostanoid metabolism P 0 0 0 0 0 1 7 8 14.3 87.5 -0.389 0004089 carbonate dehydratase F 1 7 11 14.3 63.6 1 7 11 14.3 63.6 -0.389 0004759 serine esterase F 1 7 10 14.3 70 1 7 10 14.3 70 -0.389 0006693 prostaglandin metabolism P 1 7 8 14.3 87.5 1 7 8 14.3 87.5 -0.389 0005912 adherens junction C 0 1 3 0 0 1 7 14 14.3 50 -0.389 0016718 oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous F 0 0 0 0 0 1 7 10 14.3 70 -0.389 0006886 intracellular protein transport P 14 90 113 15.6 79.6 27 143 178 18.9 80.3 -0.393 0016701 oxidoreductase, acting on single donors with incorporation of molecular oxygen F 0 0 0 0 0 5 29 38 17.2 76.3 -0.395 0006520 amino acid metabolism P 1 8 9 12.5 88.9 5 29 36 17.2 80.6 -0.395 0045087 innate immune response P 0 0 0 0 0 8 45 55 17.8 81.8 -0.403 0006954 inflammatory response P 8 44 54 18.2 81.5 8 45 55 17.8 81.8 -0.403 0016787 hydrolase F 7 16 23 43.8 69.6 112 574 821 19.5 69.9 -0.426 0008565 protein transporter F 3 17 18 17.6 94.4 4 24 25 16.7 96 -0.43 0016798 hydrolase, acting on glycosyl bonds F 0 0 0 0 0 4 24 32 16.7 75 -0.43 0004702 receptor signaling protein serine/threonine kinase F 0 5 5 0 0 2 13 18 15.4 72.2 -0.431 0006690 eicosanoid metabolism P 0 0 0 0 0 2 13 16 15.4 81.2 -0.431 0006953 acute-phase response P 2 13 13 15.4 100 2 13 13 15.4 100 -0.431 0007242 intracellular signaling cascade P 23 123 142 18.7 86.6 43 226 282 19 80.1 -0.443 0006820 anion transport P 2 7 9 28.6 77.8 6 35 49 17.1 71.4 -0.449 0000004 biological_process unknown P 18 98 250 18.4 39.2 18 98 250 18.4 39.2 -0.452 0005578 extracellular matrix C 7 36 51 19.4 70.6 13 72 94 18.1 76.6 -0.453 0005792 microsome C 8 46 55 17.4 83.6 8 46 55 17.4 83.6 -0.473 0019725 homeostasis P 0 0 0 0 0 3 19 30 15.8 63.3 -0.478 0016741 transferase, transferring one-carbon groups F 0 0 0 0 0 3 19 29 15.8 65.5 -0.478 0004299 proteasome endopeptidase F 3 19 19 15.8 100 3 19 19 15.8 100 -0.478 0004298 threonine endopeptidase F 0 0 0 0 0 3 19 19 15.8 100 -0.478 0016789 carboxylic ester hydrolase F 0 6 7 0 0 3 19 22 15.8 86.4 -0.478 0007264 small GTPase mediated signal transduction P 8 48 56 16.7 85.7 11 62 74 17.7 83.8 -0.481 0015291 porter F 0 0 0 0 0 7 41 56 17.1 73.2 -0.498 0007169 transmembrane receptor protein tyrosine kinase signaling pathway P 5 36 44 13.9 81.8 7 41 52 17.1 78.8 -0.498 0005581 collagen C 4 25 31 16 80.6 4 25 31 16 80.6 -0.522 0030020 extracellular matrix structural constituent conferring tensile strength F 4 25 31 16 80.6 4 25 31 16 80.6 -0.522 0005096 GTPase activator F 4 23 34 17.4 67.6 4 25 38 16 65.8 -0.522 0008219 cell death P 1 2 2 50 100 19 105 135 18.1 77.8 -0.538 0006779 porphyrin biosynthesis P 0 6 7 0 0 1 8 9 12.5 88.9 -0.542 0008514 organic anion transporter F 1 2 3 50 66.7 1 8 11 12.5 72.7 -0.542 0005549 odorant binding F 0 2 4 0 0 1 8 10 12.5 80 -0.542 0006783 heme biosynthesis P 1 8 9 12.5 88.9 1 8 9 12.5 88.9 -0.542 0015294 solute:cation symporter F 0 0 0 0 0 1 8 14 12.5 57.1 -0.542 0005530 lectin F 0 6 18 0 0 1 8 21 12.5 38.1 -0.542 0006766 vitamin metabolism P 0 1 1 0 0 1 8 10 12.5 80 -0.542 0004522 pancreatic ribonuclease F 1 8 9 12.5 88.9 1 8 9 12.5 88.9 -0.542 0016892 endoribonuclease, producing other than 5’-phosphomonoesters F 0 0 0 0 0 1 8 9 12.5 88.9 -0.542 0015203 polyamine transporter F 0 0 0 0 0 1 8 9 12.5 88.9 -0.542 0005279 amino acid-polyamine transporter F 1 8 9 12.5 88.9 1 8 9 12.5 88.9 -0.542 0004221 ubiquitin C-terminal hydrolase F 1 8 14 12.5 57.1 1 8 14 12.5 57.1 -0.542 0005085 guanyl-nucleotide exchange factor F 2 11 15 18.2 73.3 2 14 18 14.3 77.8 -0.55 0030136 clathrin-coated vesicle C 0 0 0 0 0 2 14 24 14.3 58.3 -0.55 0005243 gap-junction forming channel F 2 14 16 14.3 87.5 2 14 16 14.3 87.5 -0.55 0015285 connexon channel F 2 14 14 14.3 100 2 14 14 14.3 100 -0.55 0015293 symporter F 0 0 0 0 0 2 14 21 14.3 66.7 -0.55 0016229 steroid dehydrogenase F 0 0 1 0 0 2 14 16 14.3 87.5 -0.55 0005922 connexon C 2 14 14 14.3 100 2 14 14 14.3 100 -0.55 0006334 nucleosome assembly P 2 14 17 14.3 82.4 2 14 17 14.3 82.4 -0.55 0007399 neurogenesis P 7 41 54 17.1 75.9 13 74 105 17.6 70.5 -0.564 0016329 apoptosis regulator F 5 21 27 23.8 77.8 5 31 43 16.1 72.1 -0.564 0015290 electrochemical potential-driven transporter F 0 1 1 0 0 7 42 57 16.7 73.7 -0.57 0016337 cell-cell adhesion P 1 4 5 25 80 3 20 30 15 66.7 -0.578 0006508 proteolysis and peptidolysis P 26 126 155 20.6 81.3 31 169 215 18.3 78.6 -0.606 0030163 protein degradation P 0 2 3 0 0 31 170 217 18.2 78.3 -0.644 0008135 translation factor, nucleic acid binding F 0 0 0 0 0 5 32 43 15.6 74.4 -0.644 0045182 translation regulator F 0 0 0 0 0 5 32 43 15.6 74.4 -0.644 0005615 extracellular space C 2 15 19 13.3 78.9 2 15 19 13.3 78.9 -0.662 0005921 gap junction C 2 15 17 13.3 88.2 2 15 17 13.3 88.2 -0.662 0007156 homophilic cell adhesion P 2 15 22 13.3 68.2 2 15 22 13.3 68.2 -0.662 0003925 small monomeric GTPase F 6 36 42 16.7 85.7 6 38 46 15.8 82.6 -0.677 0006997 nuclear organization and biogenesis P 1 1 2 100 50 6 38 53 15.8 71.7 -0.677 0006865 amino acid transport P 1 9 9 11.1 100 1 9 10 11.1 90 -0.678 0004869 cysteine protease inhibitor F 1 9 13 11.1 69.2 1 9 13 11.1 69.2 -0.678 0005024 transforming growth factor-beta receptor F 1 9 9 11.1 100 1 9 9 11.1 100 -0.678 0006414 protein synthesis elongation P 1 9 37 11.1 24.3 1 9 37 11.1 24.3 -0.678 0005184 neuropeptide hormone F 0 5 8 0 0 1 9 13 11.1 69.2 -0.678 0006778 porphyrin metabolism P 0 0 0 0 0 1 9 11 11.1 81.8 -0.678 0007265 RAS protein signal transduction P 1 9 12 11.1 75 1 9 12 11.1 75 -0.678 0005275 amine/polyamine transporter F 0 0 0 0 0 1 9 11 11.1 81.8 -0.678 0006730 one-carbon compound metabolism P 1 9 13 11.1 69.2 1 9 13 11.1 69.2 -0.678 0005802 Golgi trans-face C 1 9 15 11.1 60 1 9 15 11.1 60 -0.678 0001508 action potential regulation P 0 2 2 0 0 1 9 11 11.1 81.8 -0.678 0005789 endoplasmic reticulum membrane C 1 7 11 14.3 63.6 1 9 13 11.1 69.2 -0.678 0008138 protein tyrosine/serine/threonine phosphatase F 1 9 10 11.1 90 1 9 10 11.1 90 -0.678 0008303 caspase C 1 9 9 11.1 100 1 9 9 11.1 100 -0.678 0004540 ribonuclease F 0 0 4 0 0 1 9 17 11.1 52.9 -0.678 0004521 endoribonuclease F 0 0 0 0 0 1 9 12 11.1 75 -0.678 0042168 heme metabolism P 0 0 0 0 0 1 9 11 11.1 81.8 -0.678 0008217 blood pressure regulation P 1 9 10 11.1 90 1 9 10 11.1 90 -0.678 0008632 apoptotic program P 0 3 3 0 0 1 9 9 11.1 100 -0.678 0004842 ubiquitin-protein ligase F 1 9 11 11.1 81.8 1 9 11 11.1 81.8 -0.678 0005905 coated pit C 1 9 16 11.1 56.2 1 9 16 11.1 56.2 -0.678 0009057 macromolecule catabolism P 0 0 0 0 0 31 171 219 18.1 78.1 -0.681 0004872 receptor F 8 42 73 19 57.5 85 449 694 18.9 64.7 -0.694 0005254 chloride channel F 0 0 0 0 0 4 27 38 14.8 71.1 -0.697 0016779 nucleotidyltransferase F 1 1 1 100 100 5 33 41 15.2 80.5 -0.722 0019207 kinase regulator F 0 0 0 0 0 5 33 42 15.2 78.6 -0.722 0012501 programmed cell death P 0 0 0 0 0 18 104 134 17.3 77.6 -0.738 0006915 apoptosis P 16 88 109 18.2 80.7 18 104 134 17.3 77.6 -0.738 0019887 protein kinase regulator F 0 0 0 0 0 3 22 30 13.6 73.3 -0.766 0006917 induction of apoptosis P 2 13 21 15.4 61.9 2 16 24 12.5 66.7 -0.767 0012502 induction of programmed cell death P 0 0 0 0 0 2 16 24 12.5 66.7 -0.767 0008066 glutamate receptor F 0 0 0 0 0 2 16 21 12.5 76.2 -0.767 0008305 integrin C 2 16 17 12.5 94.1 2 16 17 12.5 94.1 -0.767 0008014 calcium-dependent cell adhesion molecule F 2 16 21 12.5 76.2 2 16 21 12.5 76.2 -0.767 0008287 protein serine/threonine phosphatase C 2 15 18 13.3 83.3 2 16 20 12.5 80 -0.767 0009611 response to wounding P 0 0 1 0 0 9 56 95 16.1 58.9 -0.771 0030234 enzyme regulator F 0 0 0 0 0 25 142 192 17.6 74 -0.776 0008083 growth factor F 4 25 30 16 83.3 4 28 34 14.3 82.4 -0.779 0005253 anion channel F 0 0 0 0 0 4 28 41 14.3 68.3 -0.779 0007398 ectoderm development P 0 0 0 0 0 13 78 110 16.7 70.9 -0.78 0008373 sialyltransferase F 1 8 8 12.5 100 1 10 10 10 100 -0.803 0016881 acid-D-amino acid ligase F 0 0 0 0 0 1 10 16 10 62.5 -0.803 0005181 glycopeptide hormone F 1 10 10 10 100 1 10 10 10 100 -0.803 0003931 RHO small monomeric GTPase F 1 10 10 10 100 1 10 10 10 100 -0.803 0004177 aminopeptidase F 1 8 10 12.5 80 1 10 12 10 83.3 -0.803 0015171 amino acid transporter F 0 0 0 0 0 1 10 13 10 76.9 -0.803 0016764 transferase, transferase, transferring other glycosyl groups F 0 0 0 0 0 1 10 10 10 100 -0.803 0004675 transmembrane receptor protein serine/threonine kinase F 1 10 10 10 100 1 10 10 10 100 -0.803 0008236 serine-type peptidase F 1 4 8 25 50 14 84 123 16.7 68.3 -0.81 0005057 receptor signaling protein F 0 5 7 0 0 14 84 128 16.7 65.6 -0.81 0006355 transcription regulation P 101 539 686 18.7 78.6 104 551 719 18.9 76.6 -0.813 0016310 phosphorylation P 0 0 0 0 0 33 186 228 17.7 81.6 -0.846 0006796 phosphate metabolism P 0 0 0 0 0 41 228 278 18 82 -0.848 0006351 transcription, DNA-dependent P 0 1 3 0 0 105 558 732 18.8 76.2 -0.855 0015031 protein transport P 5 19 23 26.3 82.6 28 160 207 17.5 77.3 -0.86 0005911 intercellular junction C 0 1 2 0 0 4 29 39 13.8 74.4 -0.86 0030135 coated vesicle C 0 0 0 0 0 2 17 27 11.8 63 -0.866 0006873 ion homeostasis P 0 0 1 0 0 2 17 28 11.8 60.7 -0.866 0030003 cation homeostasis P 0 0 0 0 0 2 17 27 11.8 63 -0.866 0006821 chloride transport P 2 17 26 11.8 65.4 2 17 26 11.8 65.4 -0.866 0004714 transmembrane receptor protein tyrosine kinase F 4 21 22 19 95.5 5 35 39 14.3 89.7 -0.872 0008047 enzyme activator F 0 3 3 0 0 5 35 49 14.3 71.4 -0.872 0005554 molecular_function unknown F 15 91 230 16.5 39.6 15 91 230 16.5 39.6 -0.887 0008202 steroid metabolism P 2 5 7 40 71.4 6 41 53 14.6 77.4 -0.889 0005576 extracellular C 29 162 213 17.9 76.1 44 245 321 18 76.3 -0.89 0003700 transcription factor F 69 369 474 18.7 77.8 71 386 507 18.4 76.1 -0.913 0006807 nitrogen metabolism P 0 2 2 0 0 1 11 11 9.1 100 -0.917 0003747 translation release factor F 0 0 0 0 0 1 11 14 9.1 78.6 -0.917 0008079 translation termination factor F 0 0 0 0 0 1 11 14 9.1 78.6 -0.917 0004527 exonuclease F 0 4 7 0 0 1 11 15 9.1 73.3 -0.917 0005923 tight junction C 1 11 15 9.1 73.3 1 11 15 9.1 73.3 -0.917 0004428 inositol/phosphatidylinositol kinase F 1 6 8 16.7 75 1 11 14 9.1 78.6 -0.917 0008207 C21-steroid metabolism P 0 0 0 0 0 1 11 13 9.1 84.6 -0.917 0008639 small protein conjugating enzyme F 0 0 0 0 0 1 11 13 9.1 84.6 -0.917 0004840 ubiquitin conjugating enzyme F 1 11 13 9.1 84.6 1 11 13 9.1 84.6 -0.917 0004199 caspase F 1 11 11 9.1 100 1 11 11 9.1 100 -0.917 0006700 C21-steroid hormone biosynthesis P 1 11 13 9.1 84.6 1 11 13 9.1 84.6 -0.917 0005635 nuclear membrane C 0 3 4 0 0 1 11 18 9.1 61.1 -0.917 0005003 ephrin receptor F 1 11 12 9.1 91.7 1 11 13 9.1 84.6 -0.917 0016684 oxidoreductase, acting on peroxide as acceptor F 0 0 0 0 0 1 11 13 9.1 84.6 -0.917 0006804 peroxidase reaction P 1 11 14 9.1 78.6 1 11 14 9.1 78.6 -0.917 0008021 synaptic vesicle C 1 11 18 9.1 61.1 1 11 18 9.1 61.1 -0.917 0007602 phototransduction P 1 9 14 11.1 64.3 1 11 16 9.1 68.8 -0.917 0004601 peroxidase F 0 6 6 0 0 1 11 12 9.1 91.7 -0.917 0019839 guanyl-nucleotide release factor F 1 11 14 9.1 78.6 1 11 14 9.1 78.6 -0.917 0006350 transcription P 3 12 15 25 80 106 566 743 18.7 76.2 -0.919 0007167 enzyme linked receptor protein signaling pathway P 1 1 1 100 100 13 81 103 16 78.6 -0.934 0005194 cell adhesion molecule F 7 34 43 20.6 79.1 11 70 91 15.7 76.9 -0.938 0005694 chromosome C 0 1 1 0 0 5 36 55 13.9 65.5 -0.944 0004721 protein phosphatase F 5 24 27 20.8 88.9 9 59 79 15.3 74.7 -0.949 0004722 protein serine/threonine phosphatase F 2 16 19 12.5 84.2 2 18 27 11.1 66.7 -0.96 0005231 excitatory extracellular ligand-gated ion channel F 0 0 0 0 0 2 18 21 11.1 85.7 -0.96 0008026 ATP dependent helicase F 2 15 18 13.3 83.3 2 18 23 11.1 78.3 -0.96 0004252 serine-type endopeptidase F 13 77 114 16.9 67.5 13 82 120 15.9 68.3 -0.985 0006468 protein amino acid phosphorylation P 30 174 209 17.2 83.3 32 185 221 17.3 83.7 -0.997 0007155 cell adhesion P 29 164 206 17.7 79.6 29 169 216 17.2 78.2 -0.997 0004888 transmembrane receptor F 4 21 35 19 60 67 369 577 18.2 64 -1.009 0019955 cytokine binding F 0 1 1 0 0 5 37 43 13.5 86 -1.014 0007001 chromosome organization and biogenesis (sensu Eukarya) P 3 20 27 15 74.1 5 37 51 13.5 72.5 -1.014 0019825 oxygen binding F 0 0 0 0 0 1 12 17 8.3 70.6 -1.024 0006875 metal ion homeostasis P 0 0 0 0 0 1 12 21 8.3 57.1 -1.024 0006916 anti-apoptosis P 1 12 19 8.3 63.2 1 12 19 8.3 63.2 -1.024 0006310 DNA recombination P 1 12 12 8.3 100 1 12 13 8.3 92.3 -1.024 0006512 ubiquitin cycle P 1 11 14 9.1 78.6 1 12 16 8.3 75 -1.024 0030005 di-, tri-valent inorganic cation homeostasis P 0 0 0 0 0 1 12 20 8.3 60 -1.024 0003735 structural constituent of ribosome F 13 83 101 15.7 82.2 13 83 101 15.7 82.2 -1.035 0004895 cell adhesion receptor F 2 18 20 11.1 90 2 19 22 10.5 86.4 -1.05 0016055 Wnt receptor signaling pathway P 1 2 4 50 50 2 19 24 10.5 79.2 -1.05 0030528 transcription regulator F 0 0 2 0 0 74 407 544 18.2 74.8 -1.052 0005882 intermediate filament C 6 44 55 13.6 80 6 44 55 13.6 80 -1.087 0045111 intermediate filament cytoskeleton C 0 0 0 0 0 6 44 55 13.6 80 -1.087 0005125 cytokine F 15 98 118 15.3 83.1 22 134 163 16.4 82.2 -1.101 0004672 protein kinase F 29 171 206 17 83 46 263 336 17.5 78.3 -1.119 0008233 peptidase F 9 43 52 20.9 82.7 36 210 308 17.1 68.2 -1.122 0007214 gamma-amino butyric acid signaling pathway P 1 13 17 7.7 76.5 1 13 17 7.7 76.5 -1.123 0005829 cytosol C 6 27 41 22.2 65.9 13 85 112 15.3 75.9 -1.133 0006333 chromatin assembly/disassembly P 0 6 8 0 0 2 20 25 10 80 -1.137 0007218 neuropeptide signaling pathway P 2 20 27 10 74.1 2 20 27 10 74.1 -1.137 0019199 transmembrane receptor protein kinase F 0 0 0 0 0 6 45 49 13.3 91.8 -1.15 0016327 apicolateral plasma membrane C 0 0 0 0 0 4 33 45 12.1 73.3 -1.157 0007186 G-protein coupled receptor protein signaling pathway P 37 206 306 18 67.3 43 249 370 17.3 67.3 -1.177 0006325 establishment and/or maintenance of chromatin architecture P 1 2 3 50 66.7 3 27 35 11.1 77.1 -1.177 0006464 protein modification P 4 21 23 19 91.3 49 281 336 17.4 83.6 -1.182 0004497 monooxygenase F 7 51 74 13.7 68.9 7 52 75 13.5 69.3 -1.214 0007389 pattern specification P 5 40 49 12.5 81.6 5 40 49 12.5 81.6 -1.215 0004970 ionotropic glutamate receptor F 1 12 12 8.3 100 1 14 15 7.1 93.3 -1.217 0015256 monocarboxylate channel F 0 0 0 0 0 1 14 15 7.1 93.3 -1.217 0005234 glutamate-gated ion channel F 1 10 10 10 100 1 14 15 7.1 93.3 -1.217 0007223 frizzled-2 receptor signaling pathway P 1 14 17 7.1 82.4 1 14 17 7.1 82.4 -1.217 0003801 blood coagulation factor F 1 10 10 10 100 1 14 14 7.1 100 -1.217 0015259 glutamate channel F 0 0 0 0 0 1 14 15 7.1 93.3 -1.217 0016917 GABA receptor F 0 0 0 0 0 2 21 26 9.5 80.8 -1.219 0005237 inhibitory extracellular ligand-gated ion channel F 0 0 0 0 0 2 21 26 9.5 80.8 -1.219 0004890 GABA-A receptor F 2 21 26 9.5 80.8 2 21 26 9.5 80.8 -1.219 0030054 cell junction C 0 0 0 0 0 4 34 48 11.8 70.8 -1.227 0005557 lymphocyte antigen F 8 59 64 13.6 92.2 8 59 64 13.6 92.2 -1.275 0007154 cell communication P 3 18 19 16.7 94.7 219 1160 1631 18.9 71.1 -1.277 0005529 sugar binding F 4 34 40 11.8 85 5 41 60 12.2 68.3 -1.279 0030246 carbohydrate binding F 0 0 0 0 0 5 41 60 12.2 68.3 -1.279 0004871 signal transducer F 17 74 98 23 75.5 144 779 1132 18.5 68.8 -1.293 0042165 neurotransmitter binding F 0 0 0 0 0 2 22 29 9.1 75.9 -1.299 0007160 cell-matrix adhesion P 2 22 23 9.1 95.7 2 22 23 9.1 95.7 -1.299 0030594 neurotransmitter receptor F 0 0 0 0 0 2 22 29 9.1 75.9 -1.299 0005207 extracellular matrix glycoprotein F 1 15 16 6.7 93.8 1 15 16 6.7 93.8 -1.306 0006836 neurotransmitter transport P 1 15 18 6.7 83.3 1 15 18 6.7 83.3 -1.306 0006897 endocytosis P 1 11 17 9.1 64.7 1 15 24 6.7 62.5 -1.306 0008372 cellular_component unknown C 18 117 291 15.4 40.2 18 117 291 15.4 40.2 -1.309 0006511 ubiquitin-dependent protein degradation P 5 39 51 12.8 76.5 5 42 57 11.9 73.7 -1.342 0003685 DNA repair protein F 0 16 19 0 0 2 23 27 8.7 85.2 -1.376 0005126 hematopoeitin/interferon-class (D200-domain) cytokine receptor ligand F 2 13 15 15.4 86.7 2 23 27 8.7 85.2 -1.376 0000139 Golgi membrane C 1 16 18 6.2 88.9 1 16 18 6.2 88.9 -1.391 0004713 protein tyrosine kinase F 15 99 114 15.2 86.8 15 102 118 14.7 86.4 -1.393 0019941 protein-ligand dependent protein degradation P 0 0 0 0 0 5 43 58 11.6 74.1 -1.404 0004519 endonuclease F 2 24 30 8.3 80 2 24 33 8.3 72.7 -1.45 0016758 transferase, transferring hexosyl groups F 0 3 4 0 0 3 31 42 9.7 73.8 -1.462 0016810 hydrolase, acting on carbon-nitrogen (but not peptide) bonds F 0 2 2 0 0 1 17 28 5.9 60.7 -1.471 0009101 glycoprotein biosynthesis P 0 0 0 0 0 1 17 20 5.9 85 -1.471 0019538 protein metabolism P 0 0 1 0 0 1 17 22 5.9 77.3 -1.471 0006486 protein amino acid glycosylation P 1 12 14 8.3 85.7 1 17 20 5.9 85 -1.471 0009100 glycoprotein metabolism P 0 0 0 0 0 1 17 21 5.9 81 -1.471 0016757 transferase, transferring glycosyl groups F 0 0 0 0 0 6 51 64 11.8 79.7 -1.506 0007596 blood coagulation P 2 25 28 8 89.3 2 25 28 8 89.3 -1.521 0004518 nuclease F 1 16 23 6.2 69.6 3 32 50 9.4 64 -1.528 0003678 DNA helicase F 3 32 55 9.4 58.2 3 32 55 9.4 58.2 -1.528 0006694 steroid biosynthesis P 2 23 29 8.7 79.3 3 32 42 9.4 76.2 -1.528 0004386 helicase F 2 15 18 13.3 83.3 3 32 57 9.4 56.1 -1.528 0005230 extracellular ligand-gated ion channel F 2 21 25 9.5 84 4 39 47 10.3 83 -1.55 0005180 peptide hormone F 2 23 27 8.7 85.2 4 39 47 10.3 83 -1.55 0015276 ligand-gated ion channel F 0 0 0 0 0 5 46 58 10.9 79.3 -1.581 0006281 DNA repair P 5 43 48 11.6 89.6 5 46 53 10.9 86.8 -1.581 0005840 ribosome C 3 48 56 6.2 85.7 9 71 93 12.7 76.3 -1.588 0007599 hemostasis P 0 1 2 0 0 2 26 29 7.7 89.7 -1.591 0007229 integrin-mediated signaling pathway P 2 26 32 7.7 81.2 2 26 32 7.7 81.2 -1.591 0004930 G-protein coupled receptor F 25 160 205 15.6 78 27 175 276 15.4 63.4 -1.597 0007582 physiological processes P 3 8 12 37.5 66.7 7 59 75 11.9 78.7 -1.602 0005179 hormone F 3 25 29 12 86.2 6 53 62 11.3 85.5 -1.616 0005102 ligand F 1 18 26 5.6 69.2 33 210 267 15.7 78.7 -1.65 0007268 synaptic transmission P 6 51 64 11.8 79.7 6 55 73 10.9 75.3 -1.723 0005717 chromatin C 0 17 21 0 0 2 28 41 7.1 68.3 -1.724 0006935 chemotaxis P 4 42 50 9.5 84 4 42 50 9.5 84 -1.728 0000067 DNA replication and chromosome cycle P 0 0 0 0 0 5 49 62 10.2 79 -1.749 0006323 DNA packaging P 0 9 11 0 0 3 36 46 8.3 78.3 -1.778 0019226 transmission of nerve impulse P 0 0 0 0 0 7 64 84 10.9 76.2 -1.855 0007049 cell cycle P 7 90 107 7.8 84.1 37 240 291 15.4 82.5 -1.888 0004002 adenosinetriphosphatase F 0 3 4 0 0 2 31 38 6.5 81.6 -1.911 0009058 biosynthesis P 2 8 11 25 72.7 37 242 334 15.3 72.5 -1.947 0000084 S phase of mitotic cell cycle P 0 0 0 0 0 4 46 55 8.7 83.6 -1.95 0006260 DNA replication P 3 37 42 8.1 88.1 4 46 55 8.7 83.6 -1.95 0005783 endoplasmic reticulum C 12 101 119 11.9 84.9 15 117 141 12.8 83 -2.009 0007178 transmembrane receptor protein serine/threonine kinase signaling pathway P 1 7 9 14.3 77.8 1 25 31 4 80.6 -2.021 0007267 cell-cell signaling P 4 30 35 13.3 85.7 11 94 119 11.7 79 -2.069 0006411 protein metabolism and modification P 0 2 4 0 0 108 633 811 17.1 78.1 -2.105 0001584 rhodopsin-like receptor F 0 0 0 0 0 4 49 107 8.2 45.8 -2.107 0016192 vesicle-mediated transport P 1 15 24 6.7 62.5 2 35 55 5.7 63.6 -2.14 0007046 ribosome biogenesis P 1 27 33 3.7 81.8 1 28 37 3.6 75.7 -2.196 0042254 ribosome biogenesis and assembly P 0 0 0 0 0 1 28 37 3.6 75.7 -2.196 0006412 protein biosynthesis P 10 90 110 11.1 81.8 12 104 152 11.5 68.4 -2.221 0007166 cell surface receptor linked signal transduction P 6 35 44 17.1 79.5 66 414 586 15.9 70.6 -2.252 0007165 signal transduction P 30 146 182 20.5 80.2 116 688 922 16.9 74.6 -2.353 0008528 peptide receptor, G-protein coupled F 0 2 3 0 0 1 31 35 3.2 88.6 -2.36 0005794 Golgi apparatus C 9 87 108 10.3 80.6 11 103 133 10.7 77.4 -2.429 0006397 mRNA processing P 1 14 20 7.1 70 1 33 45 3 73.3 -2.463 0016070 RNA metabolism P 0 0 1 0 0 2 44 66 4.5 66.7 -2.596 0005667 transcription factor complex C 32 234 303 13.7 77.2 32 236 306 13.6 77.1 -2.602 0009059 macromolecule biosynthesis P 0 0 0 0 0 13 121 172 10.7 70.3 -2.621 0003674 molecular_function F 0 0 0 0 0 783 3999 5846 19.6 68.4 -2.663 0005654 nucleoplasm C 1 4 7 25 57.1 34 252 329 13.5 76.6 -2.721 0000278 mitotic cell cycle P 0 1 1 0 0 5 70 89 7.1 78.7 -2.738 0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism P 1 1 2 100 50 123 748 981 16.4 76.2 -2.783 0003723 RNA binding F 10 94 121 10.6 77.7 11 113 155 9.7 72.9 -2.801 0006396 RNA processing P 0 6 11 0 0 1 41 60 2.4 68.3 -2.843 0005488 ligand binding or carrier F 7 24 29 29.2 82.8 367 2012 2877 18.2 69.9 -2.895 0006259 DNA metabolism P 1 7 9 14.3 77.8 13 135 163 9.6 82.8 -3.1 0003677 DNA binding F 106 662 933 16 71 117 739 1069 15.8 69.1 -3.215 0005634 nucleus C 141 898 1211 15.7 74.2 145 949 1326 15.3 71.6 -4.224 0003676 nucleic acid binding F 18 141 181 12.8 77.9 131 877 1264 14.9 69.4 -4.302