Biology for the post-genomic era
Fully Open Access. Genome Biology covers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research, new methods and software tools, and reviews, opinions and commentaries. Areas covered include, but are not limited to: sequence analysis; bioinformatics; insights into molecular, cellular and organismal biology; functional genomics; epigenomics; population genomics; proteomics; comparative biology and evolution; systems and network biology; genomics of disease; and clinical genomics. All content is open access immediately on publication.
- Louisa Flintoft PhD, Genome Biology
Advantages over clinical exome sequencing can be achieved by using an NGS-based multiplexing assay involving comprehensive gene panels.
An analysis finds that increasing the read length for RNA-seq studies does not improve ability to detect differential expression
The DNA binding domain of the Forkhead transcription factor FOXM1 is essential for binding to non-consensus sequences through protein-protein interactions.
Alex Shalek and colleagues describe the latest developments in the microfluidic technology enabling single-cell sequencing studies
A systems level analysis of epithelial-stromal interactions in invasive breast cancer reveals the co-expression self-loops
A single-cell transcriptomic analysis of lung adenocarcinoma patient derived xenografts reveals heterogeneity in the response to anti-cancer drugs
A new algorithm detects circular RNAs with high sensitivity and specificity and discovers human fetal brain regions enriched for circular RNA isoforms
In this Review, Srinivasan Chandrasegaran and colleagues explore the exciting advances in DNA synthesis and assembly methods made over the past decade.
UPP is a method for ultra-large multiple sequence alignments using phylogeny-aware profiles, based on an ensemble of hidden Markov models
A screen for DNA methylated regions affected by season of conception in rural Gambia identifies VTRNA2-1 as an environmental epiallele
iCLIP in Drosophila shows that Imp RNPs participate in actin cytoskeletal remodeling
Latest articles from Genome Medicine
Genome Medicine 2015, 7:62
Genome Medicine 2015, 7:61
Genome Medicine 2015, 7:60
Genome Medicine 2015, 7:55