Biology for the post-genomic era

Fully Open Access. Genome Biology covers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research, new methods and software tools, and reviews, opinions and commentaries. Areas covered include, but are not limited to: sequence analysis; bioinformatics; insights into molecular, cellular and organismal biology; functional genomics; epigenomics; population genomics; proteomics; comparative biology and evolution; systems and network biology; genomics of disease; and clinical genomics. All content is open access immediately on publication.


  • Louisa Flintoft PhD, Genome Biology


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  • Microbiome profiling from biopsies

    Doron Betel and colleagues describe methodology for the identification of pathogens from low bacterial abundance human WGS datasets

    Genome Biology 2015, 16:265
  • Down syndrome methylation

    Novel biological mechanisms are implicated in the development of Down syndrome by studying methylation patterns in humans and mice

    Genome Biology 2015, 16:263
  • S. aureus alternative Cas9

    A characterization of an alternative, Staphylococcus aureus-derived Cas9 nuclease and the design of all-in-one vector

    Genome Biology 2015, 16:257
  • p16 DNA methylation drives metastasis

    Engineered zinc finger methyltransferases provide insights into the role of p16 methylation in cancer metastasis

    Genome Biology 2015, 16:252
  • Cas9 PAM characterization

    A new in vitro method for simultaneous examination of guide RNA and PAM requirements for CRISPR-based experiments

    Genome Biology 2015, 16:253
  • Global fight with infectious diseases

    Amy Cain and John Lees report from the Infectious Disease Genomics conference on the applications of genomics to human health

    Genome Biology 2015, 16:250
  • Novel CRISPR nuclease

    Peter Fineran and colleagues discuss the discovery and the biotechnological potential of a novel endonuclease, Cpf1

    Genome Biology 2015, 16:251
  • Plasmodium attenuation with ZFNs

    Hundreds of genes are removed from Plasmodium’s chromosome by ZFN-based DNA editing and repaired through MMEJ

    Genome Biology 2015, 16:249
  • CRISPR/Cas9-mediated virus interference

    An application of CRISPR/Cas9-based technology to confer immunity against DNA viruses in plants

    Genome Biology 2015, 16:238
  • Pop in, pop out

    Ralf Kühn and Van Chu highlight a novel targeting strategy for the genome editing experiments on low abundant genes

    Genome Biology 2015, 16:244
  • Editing low abundance genes

    A novel approach for efficient CRISPR/Cas homologous recombination-based editing of low abundance genes provides insights into TERT trafficking

    Genome Biology 2015, 16:231
Genome Editing: read the special issue
Single-cell omics: call for papers
Wheat genomics: featured research
3D Organization of the Nucleus
Avian Genomes collection

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ISSN: 1474-760X