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  • Image attributed to: A panel of clinicians

    Diagnosing Mendelian diseases

    Advantages over clinical exome sequencing can be achieved by using an NGS-based multiplexing assay involving comprehensive gene panels.

    Genome Biology 2015, 16:134
  • Read length cost-benefit

    An analysis finds that increasing the read length for RNA-seq studies does not improve ability to detect differential expression

    Genome Biology 2015, 16:131
  • FOXM1 in chromatin recruitment

    The DNA binding domain of the Forkhead transcription factor FOXM1 is essential for binding to non-consensus sequences through protein-protein interactions.

    Genome Biology 2015, 16:130
  • Marrying microfluidics & microwells

    Alex Shalek and colleagues describe the latest developments in the microfluidic technology enabling single-cell sequencing studies

    Genome Biology 2015, 16:129
  • Breast cancer-stroma interactions

    A systems level analysis of epithelial-stromal interactions in invasive breast cancer reveals the co-expression self-loops

    Genome Biology 2015, 16:128
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