The 219 proteins that were assigned a binding preference for at least one nucleic acid subtype have been clustered to reflect similarities in preferences (affinity fingerprint). Most protein families show similar preferences. In contrast, H1FX was found to be RNA-specific as opposed to the family members H1F0 and HIST1H1C, which were DNA-specific.
Dürnberger et al. Genome Biology 2013 14:R81 doi:10.1186/gb-2013-14-7-r81