Additional file 18.

CpG and GpC O/E ratios by GC content. Genes and genomic fragments were divided into five groups according to their G+C content. Our results show that across all the groups, CpG O/E values of CDS are still significantly lower than that of the genome background when GC content is minimized, while GpC O/E values of CDS are highly similar to those of genome background.

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Kocher et al. Genome Biology 2013 14:R142   doi:10.1186/gb-2013-14-12-r142