Additional file 8.

Stratification of clades associated with IBD status by sample biogeography. Fifteen microbial clades were significantly associated specifically with IBD status (q < 0.25) using a multivariate linear model incorporating clinical metadata (see Materials and methods). Although this model putatively asserts that this association holds regardless of sample origin (biopsy or stool), we verified this by stratifying each clade's abundance by sample type, stool (1) or biopsy (0). Green coloring indicates that a clade's abundance was significantly reduced in IBD using the full model, red increased. These trends are uniformly preserved after explicit stratification by stool versus biopsy sample origins.

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Morgan et al. Genome Biology 2012 13:R79   doi:10.1186/gb-2012-13-9-r79