Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Highly Accessed Open Badges Review

Genetic architecture of body size in mammals

Kathryn E Kemper1*, Peter M Visscher23 and Michael E Goddard14

Author affiliations

1 Faculty of Land and Environment, University of Melbourne, Parkville, Victoria 3010, Australia

2 University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia

3 The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia

4 Victorian Department of Primary Industries, AgriBiosciences Centre, LaTrobe Research and Development Park, Bundoora, Victoria 3083, Australia

For all author emails, please log on.

Citation and License

Genome Biology 2012, 13:244  doi:10.1186/gb-2012-13-4-244

Published: 30 April 2012


Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.

Human height; mutation effects; mutation-selection balance