Shortest cell processes connection gene sub-networks for genes of selected female ECR chr2-188.8 and male ECR chr1-204.75. (a) ECR chr2-188.8. (b) Male ECR chr1-204.75. Node shapes: oval and circle, protein; diamond, ligand; circle/oval on tripod platform, transcription factor; ice cream cone, receptor; crescent, kinase or protein kinase; irregular polygon, phosphatase. Color code: red, up-regulated genes; blue, down-regulated genes. Arrows with a plus sign indicate positive regulation/activation; arrows with a minus sign indicate negative regulation/inhibition; grey arrows represent regulation; lilac arrows represent expression; purple arrows represent binding; green arrows represent promoter binding; yellow arrows represent protein modification. AA, amino acid; FAS; FGF, fibroblast growth factor; INS, insulin; LRP2, low density lipoprotein receptor-related protein 2; ROS, reactive oxygen species.
Skinner et al. Genome Biology 2012 13:R91 doi:10.1186/gb-2012-13-10-r91