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Transcriptional enhancers in development and disease

Noboru Jo Sakabe*, Daniel Savic* and Marcelo A Nobrega

Author affiliations

Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA

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Citation and License

Genome Biology 2012, 13:238  doi:10.1186/gb-2012-13-1-238

Published: 23 January 2012


Distal transcription enhancers are cis-regulatory elements that promote gene expression, enabling spatiotemporal control of genetic programs such as those required in metazoan developmental processes. Because of their importance, their disruption can lead to disease.

Transcription; enhancer; development; GWAS; common disease