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DNA-protein interactions in high definition

Eric M Mendenhall123 and Bradley E Bernstein123*

Author Affiliations

1 Howard Hughes Medical Institute and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA

2 Center for Systems Biology and Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA

3 Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02139, USA

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Genome Biology 2012, 13:139  doi:10.1186/gb-2012-13-1-139

Published: 27 January 2012


An elegant, genome-wide approach to define the precise DNA sequences bound by transcription factors has been developed by Rhee and Pugh.