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This article is part of the supplement: Beyond the Genome 2011

Open Access Open Badges Invited speaker presentation

Next-generation clinical sequencing in a children’s hospital

Stephen Kingsmore

  • Correspondence: Stephen Kingsmore

Author Affiliations

Children’s Mercy Hospital, Kansas City, MO, USA

Genome Biology 2011, 12(Suppl 1):I9  doi:10.1186/gb-2011-12-s1-i9

The electronic version of this article is the complete one and can be found online at:

Published:19 September 2011

© 2011 Kingsmore; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Invited speaker presentation

Next-generation sequencing and analysis tools are reaching the mature stage at which mentioning their usefulness for clinical testing is not an oxymoron. Indeed, next-generation clinical sequencing has the potential to transform children’s health care, because inherited illnesses account for much of the childhood disease burden. I will discuss the first year of the integration of genomic medicine for Mendelian diseases at Children’s Mercy Hospital.