Copy number variation detection in chromosome 10 of a simulated sample. (a-d) CBS segmentation of chromosome 10 from the simulated sample 4 using global loess normalization (a), CGHnormaliter (b), poplowess (c), and channel clone normalization (d). The blue line represents the CBS segmentation line. The red region and green regions represent the deletion and duplication regions called by CGHcall.
Cheng et al. Genome Biology 2011 12:R80 doi:10.1186/gb-2011-12-8-r80