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Sex lethal and upstream ORFs: a bait-and-trap system for ribosomes

Peng Yao and Paul L Fox*

Author affiliations

Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA

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Citation and License

Genome Biology 2011, 12:121  doi:10.1186/gb-2011-12-7-121

Published: 25 July 2011


An upstream ORF cooperates with Sex lethal to inhibit msl-2 translation during Drosophila sex determination, a biological principle with potentially broad application in gene regulation.