Developmentally dynamic domains are enriched in regulatory genes. (a) Density of DDEs plotted across chromosome 2R. Peaks in DDE density above a statistical background (dotted grey line) were labeled by associated gene name and colored by gene ontology (GO) category. (b) The median phastcons conservation score (and 95% confidence intervals) for all DDEs that map to non-coding locations is shown alongside the median and intervals calculated for randomly chosen non-coding sites within the genome. (c) DNaseI tag density across an approximately 30-kb region of chromosome 2R around ppa, indicated with an asterisk in (a,c), illustrating an exemplary developmentally dynamic domain composed of clustered DDEs (red arrows).
Thomas et al. Genome Biology 2011 12:R43 doi:10.1186/gb-2011-12-5-r43