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Mapping of disease-associated variants in admixed populations

Daniel Shriner*, Adebowale Adeyemo, Edward Ramos, Guanjie Chen and Charles N Rotimi*

Author Affiliations

Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Drive, MSC 5635, Bethesda, MD 20892, USA

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Genome Biology 2011, 12:223  doi:10.1186/gb-2011-12-5-223

Published: 30 May 2011


Recent developments in high-throughput genotyping and whole-genome sequencing will enhance the identification of disease loci in admixed populations. We discuss how a more refined estimation of ancestry benefits both admixture mapping and association mapping, making disease loci identification in admixed populations more powerful.

High-throughput genotyping and sequencing will enable refined estimation of ancestry, thus enhancing disease loci identification in admixed populations