What does biologically meaningful mean? A perspective on gene regulatory network validation
Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Genome Biology 2011, 12:109 doi:10.1186/gb-2011-12-4-109Published: 11 April 2011
Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.