Phylogenetic and modular analysis of C. militaris polyketide synthases compared with those involved in the production of human mycotoxins. (a) A neighbor-joining tree showing the relationships of ketoacyl CoA synthase (KS) domain sequences. (b) Modulation and comparison of C. militaris PKSs with those involved in production of mycotoxins. The PKS-NRPS hybrid proteins CCM_04722, CCM_08261 and CCM_08018 are not included in the analysis. Domain definitions: ACP, acyl carrier protein domain; AT, acyltransferase domain; CYC, cyclase domain; DH, dehydratase domain; ER, enoyl reductase domain; KR, ketoreductase domain; MT, methyltransferase domain; TE, thioesterase domain. The accessions and references for different mycotoxins are provided in the Materials and methods.
Zheng et al. Genome Biology 2011 12:R116 doi:10.1186/gb-2011-12-11-r116