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Dosage compensation and the global re-balancing of aneuploid genomes

Matthias Prestel, Christian Feller and Peter B Becker*

Author Affiliations

Adolf-Butenandt-Institute and Centre for Integrated Protein Science (CiPSM), Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany

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Genome Biology 2010, 11:216  doi:10.1186/gb-2010-11-8-216

Published: 26 August 2010


Diploid genomes are exquisitely balanced systems of gene expression. The dosage-compensation systems that evolved along with monosomic sex chromosomes exemplify the intricacies of compensating for differences in gene copy number by transcriptional regulation.