Common variants in polygenic schizophrenia
1 Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
2 Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Genome Biology 2009, 10:236 doi:10.1186/gb-2009-10-9-236Published: 29 September 2009
Common variant single-nucleotide polymorphisms at the MHC locus have recently been associated with schizophrenia. Together with known associations with rare copy-number variants affecting many genes, this reveals the highly polygenic etiology of the disease.