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Conserved features of cohesin binding along fission yeast chromosomes

Christine K Schmidt13, Neil Brookes24 and Frank Uhlmann1*

Author Affiliations

1 Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields, London WC2A 3PX, UK

2 Bioinformatics and Biostatistics Service, Cancer Research UK London Research Institute, Lincoln's Inn Fields, London WC2A 3PX, UK

3 Current address: National Cancer Institute, NIH, Bethesda, MD 20892, USA

4 Current address: Trinity Centre for High Performance Computing, Trinity College, Dublin 2, Ireland

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Genome Biology 2009, 10:R52  doi:10.1186/gb-2009-10-5-r52

Published: 19 May 2009

Additional files

Additional data file 1:

Figure S1 shows cohesin association along fission yeast chromosome 2. Figure S2 is a graph depicting the maximal distance analysis between neighboring cohesin peaks. Figure S3 is a graph demonstrating higher expression levels of cohesin-bound convergent gene pairs. Figure S4 shows Mis4 and Ssl3 association along chromosome 2 and analyzing their overlap with tRNA and ribosomal protein genes. Figure S5 compares the Mis4 association pattern in exponentially growing and G1 arrested cells. Figure S6 is a graph depicting Mis4/Ssl3 binding site correlation with strongly expressed genes. Figure S7 shows that the cohesin pattern along chromosome arms remains qualitatively unchanged during cohesin removal in mitosis. Table S1 contains details on the yeast strains used in this study.

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