Comparison of sensitivity for detecting ten simulated allelic imbalances for different methods. Heterozygous SNPs in NA06991 were used to estimate the sensitivity for the methods in detecting allelic imbalances in the simulated data set with increasing normal cell contamination. Sensitivity was calculated for each method based on calls for allelic imbalance or not. Lines correspond to sensitivity for PennCNV (black), QuantiSNP (green), unpaired segmentation (red), paired segmentation (orange), and SOMATICs (blue).
Staaf et al. Genome Biology 2008 9:R136 doi:10.1186/gb-2008-9-9-r136