Additional data file 8.
A normalized co-expression similarity γ (β, complex) for all genes encoding proteins that form a complex is obtained from the adjacencies of the pairwise interactions within the complex as: γ (β, complex) = [mediani, j ∈ complexaij(β)]/mediani, j aij(β)], where the median in the denominator extends over all interactive pairs in the interactome. Similarly, the normalized structure vulnerability Λ (β, complex) for complexes is defined as Λ (β, complex) = [mediani, j ∈ complexνij(β)]/mediani, j νij(β)]. (a-c) (Λ (β, complex)-γ (β, complex)) correlation over all 98 yeast complexes with transcriptome representation for exponents β = 0.5 (a), 1 (b) and 10 (c). (d-f) The same as (a-c) but for 53 human complexes.
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Chen et al. Genome Biology 2008 9:R107 doi:10.1186/gb-2008-9-7-r107