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A role for Numb in p53 stabilization

Stephanie Carter and Karen H Vousden*

Author Affiliations

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK

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Genome Biology 2008, 9:221  doi:10.1186/gb-2008-9-5-221

Published: 9 May 2008


The cell-fate determinant Numb has recently been shown to help activate the tumor suppressor protein p53. Loss of Numb in breast cancers would result, therefore, in both the activation of the potential oncogene Notch and the diminution of tumor suppression by p53.