A tree based bracketing algorithm for phylotyping a query sequence. To assign a phylotype to the query sequence, its immediate ancestor n0 and the first internal node n1 with ≥70% bootstrapping support were identified. The known descendant leaf nodes of n1, namely A through D, are used to infer the taxonomy of the query, in conjunction with the normalized branch length information. The dashed timelines delimiting various taxonomic ranks were inferred from a clock that had been calibrated from the bacterial genome tree.
Wu and Eisen Genome Biology 2008 9:R151 doi:10.1186/gb-2008-9-10-r151