This article is part of the supplement: Transposons in vertebrate functional genomics
Transposons for cancer gene discovery: Sleeping Beauty and beyond
The Department of Genetics, Cell Biology and Development, The Cancer Center, The University of Minnesota Twin Cities, Church St SE, Minneapolis, Minnesota 55455, USA
Genome Biology 2007, 8(Suppl 1):S15 doi:10.1186/gb-2007-8-s1-s15Published: 31 October 2007
The use of Sleeping Beauty transposons as somatic mutagens to discover cancer genes in hematopoietic tumors and sarcomas has been documented. Here, we discuss the future of Sleeping Beauty for cancer genetic studies and the potential use of additional transposable elements for somatic mutagenesis.