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A small RNA makes a Bic difference

Howell F Moffett1 and Carl D Novina12*

Author affiliations

1 Cancer Immunology and AIDS, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA

2 Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA

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Citation and License

Genome Biology 2007, 8:221  doi:10.1186/gb-2007-8-7-221

Published: 31 July 2007


The first highly specific knockouts of a microRNA, miR155, in mice result in multiple defects in adaptive immunity, and also show the feasibility of investigating at least some microRNAs by gene knockout.