Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Highly Accessed Open Badges Review

Searching genomes for ribozymes and riboswitches

Christian Hammann1 and Eric Westhof2*

Author Affiliations

1 Research Group Molecular Interactions, Department of Genetics, FB 18 Naturwissenschaften, Universität Kassel, D-34132 Kassel, Germany

2 Architecture et Réactivité de l'ARN, Université Louis Pasteur de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, CNRS, rue René Descartes, F-67084 Strasbourg Cedex, France

For all author emails, please log on.

Genome Biology 2007, 8:210  doi:10.1186/gb-2007-8-4-210

Published: 30 April 2007


New regulatory RNAs with complex structures have recently been discovered, among them the first catalytic riboswitch, a gene-regulatory RNA sequence with catalytic activity. Here we discuss some of the experimental approaches and theoretical difficulties attached to the identification of new ribozymes in genomes.