Table 2 

Statistically significant genomic interactions 

First level 
Second level 
Pearson's χ^{2 }(2 d.f.) 
P value 


TNFA = 2 
D4S403 
9.10 
0.011 
TNFA = 2 
D2S177 
7.33 
0.026 
TNFA = 2 
D1S229 
6.88 
0.032 
TNFA = 1 
D11S910 
11.82 
0.0027 
TNFA = 1 
D13S170 
6.84 
0.033 
TNFA = 1 
D16S287 
6.63 
0.036 
D17S798 = 2 
D2P25 
6.41 
0.041 
D17S798 = 1 
D5S429 
7.08 
0.029 
D17S798 = 1 
D1S197 
6.94 
0.031 


Markers corresponding to the first and second level of each significant interaction, as well as Pearson χ^{2 }statistics and corresponding P value, are shown. Affected sibling pairs (ASPs) genotyped for the TNFA and D17S798 marker were as follows (nonT1D sibling pairs were simulated to be twice the number of ASPs for each group): TNFA = 2, 520 ASP and 1,040 nonT1D sibling pairs; TNFA = 1, 206 ASP and 412 nonT1D sibling pairs; D17S798 = 2, 136 ASP and 272 nonT1D sibling pairs; D17S798 = 1, 254 ASP and 508 nonT1D sibling pairs. 

Bergholdt et al. Genome Biology 2007 8:R253 doi:10.1186/gb2007811r253 