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Protein-protein interaction networks in the spinocerebellar ataxias

David C Rubinsztein

Author Affiliations

Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK

Genome Biology 2006, 7:229  doi:10.1186/gb-2006-7-8-229

Published: 10 August 2006


A large yeast two-hybrid study investigating whether the proteins mutated in different forms of spinocerebellar ataxia have interacting protein partners in common suggests that some forms do share common pathways, and will provide a valuable resource for future work on these diseases.