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Plant NBS-LRR proteins: adaptable guards

Leah McHale, Xiaoping Tan, Patrice Koehl and Richard W Michelmore*

Author Affiliations

The Genome Center, University of California, Davis, CA 95616, USA

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Genome Biology 2006, 7:212  doi:10.1186/gb-2006-7-4-212

Published: 26 April 2006


The majority of disease resistance genes in plants encode nucleotide-binding site leucine-rich repeat (NBS-LRR) proteins. This large family is encoded by hundreds of diverse genes per genome and can be subdivided into the functionally distinct TIR-domain-containing (TNL) and CC-domain-containing (CNL) subfamilies. Their precise role in recognition is unknown; however, they are thought to monitor the status of plant proteins that are targeted by pathogen effectors.