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Circadian clocks are seeing the systems biology light

Kevin R Hayes, Julie E Baggs and John B Hogenesch*

Author Affiliations

The Scripps Research Institute, 5353 Parkside Drive, Jupiter, FL 33458, USA

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Genome Biology 2005, 6:219  doi:10.1186/gb-2005-6-5-219

Published: 28 April 2005


Circadian rhythms are those biological rhythms that have a periodicity of around 24 hours. Recently, the generation of a circadian transcriptional network - compiled from RNA-expression and promoter-element analysis and phase information - has led to a better understanding of the gene-expression patterns that regulate the precise 24-hour clock.