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Systems biology approaches in cell signaling research

Raymond E Chen and Jeremy Thorner*

Author Affiliations

Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA

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Genome Biology 2005, 6:235  doi:10.1186/gb-2005-6-10-235

Published: 29 September 2005


The use of methods for global and quantitative analysis of cells is providing new systems-level insights into signal transduction processes. Recent studies reveal important information about the rates of signal transmission and propagation, help establish some general regulatory characteristics of multi-tiered signaling cascades, and illuminate the combinatorial nature of signaling specificity in cell differentiation.