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An overview of the basic helix-loop-helix proteins

Susan Jones

Author Affiliations

Department of Biochemistry, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK

Genome Biology 2004, 5:226  doi:10.1186/gb-2004-5-6-226

Published: 28 May 2004


The basic helix-loop-helix proteins are dimeric transcription factors that are found in almost all eukaryotes. In animals, they are important regulators of embryonic development, particularly in neurogenesis, myogenesis, heart development and hematopoiesis.