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Transcription-coupled mutagenesis by the DNA deaminase AID

Erik D Larson and Nancy Maizels*

Author Affiliations

Departments of Immunology and Biochemistry, University of Washington Medical School, 1959 NE Pacific Street, Seattle, WA 98195-7650, USA

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Genome Biology 2004, 5:211  doi:

Published: 27 February 2004


Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. Compelling evidence now shows that AID travels with RNA polymerase II to deaminate actively transcribed DNA.