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Hotspots of homologous recombination in the human genome: not all homologous sequences are equal

James R Lupski

Author Affiliations

Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA

Current address (sabbatical until July 2005): Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 ISA, UK

Genome Biology 2004, 5:242  doi:10.1186/gb-2004-5-10-242

Published: 28 September 2004


Homologous recombination between alleles or non-allelic paralogous sequences does not occur uniformly but is concentrated in 'hotspots' with high recombination rates. Recent studies of these hotspots show that they do not share common sequence motifs, but they do have other features in common.