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Plasmodium falciparum virulence determinants unveiled

Brendan S Crabb and Alan F Cowman

Author Affiliations

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia

Genome Biology 2002, 3:reviews1031-reviews1031.4  doi:10.1186/gb-2002-3-11-reviews1031

Published: 25 October 2002


The human malaria parasite Plasmodium falciparum, one of the world's most devastating pathogens, has an astonishing array of sequences and genes that play key roles in pathogenesis and immune evasion. We must understand the functions of these elements if the chronicity and unpredictable virulence of Plasmodium is to be explained.