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New clues to the puzzle of mammalian sex determination

Josephine Bowles and Peter Koopman*

Author Affiliations

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia

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Genome Biology 2001, 2:reviews1025-reviews1025.4  doi:10.1186/gb-2001-2-9-reviews1025

Published: 29 August 2001


WT1 and SOX9 are transcription factors with critical roles in mammalian sex determination and gonadal development. Recent studies in vivo clarify the roles of two alternative splice isoforms of WT1, and demonstrate that SOX9 can induce male sex determination.