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Functional genomics and metal metabolism

David J Eide

Author Affiliations

Department of Nutritional Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA

Genome Biology 2001, 2:reviews1028-reviews1028.3  doi:10.1186/gb-2001-2-10-reviews1028

Published: 14 September 2001


Metal ions are essential nutrients, yet they can also be toxic if they over-accumulate. Homeostatic mechanisms and detoxification systems therefore precisely control their intracellular levels and distribution. The tools of functional genomics are rapidly accelerating understanding in this field, particularly in the yeast Saccharomyces cerevisiae.