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Polymorphism in regulatory gene sequences

N A Mitchison

Author Affiliations

Department of Immunology, Windeyer Institute of Medical Science, University College London Medical School, Cleveland Street, London W1P 6DB, UK

Genome Biology 2000, 2:comment2001-comment2001.6  doi:10.1186/gb-2000-2-1-comment2001

Published: 20 December 2000


The extensive polymorphism revealed in non-coding gene-regulatory sequences, particularly in the immune system, suggests that this type of genetic variation is functionally and evolutionarily far more important than has been suspected, and provides a lead to new therapeutic strategies.