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Metabolic control analysis: biological applications and insights

Mary C Wildermuth

Author Affiliations

Department of Molecular Biology, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA

Genome Biology 2000, 1:reviews1031-reviews1031.5  doi:10.1186/gb-2000-1-6-reviews1031

Published: 8 December 2000


Metabolic control analysis provides a robust mathematical and theoretical framework for describing metabolic and signaling pathways and networks, and for quantifying the controls over these processes. Its application has already shed light on some of the principles underlying the regulation of metabolic pathways, and it is well suited to the analysis of the types of data emerging from genomic studies.