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Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes

Diarmaid Hughes

Author Affiliations

Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, S-751 24 Uppsala, Sweden

Genome Biology 2000, 1:reviews0006-reviews0006.8  doi:10.1186/gb-2000-1-6-reviews0006

Published: 8 December 2000


Inversions and translocations distinguish the genomes of closely related bacterial species, but most of these rearrangements preserve the relationship between the rearranged fragments and the axis of chromosome replication. Within species, such rearrangements are found less frequently, except in the case of clinical isolates of human pathogens, where rearrangements are very frequent