Figure 1.

V(D)J recombination occurs in several steps. First, the RAG proteins bind to the RSSs (triangles) and bring them together into a synaptic complex. Cleavage ensues, generating a pair of blunt signal ends and a pair of DNA hairpin coding ends. Joining of these ends generates signal and coding joints, respectively. The boxes represent V, D or J coding elements.

Roth Genome Biology 2000 1:reviews1014.1-reviews1014.4   doi:10.1186/gb-2000-1-2-reviews1014