A molecular portrait of the response to unfolded proteins
1 Department of Biology, University of Nevada, Reno, NV 89557, USA
2 Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
Genome Biology 2000, 1:reviews1013-reviews1013.3 doi:10.1186/gb-2000-1-2-reviews1013Published: 4 August 2000
Using DNA microarrays, 381 genes have been found to be induced in response to unfolded proteins. The identity of the previously characterized 208 of these, and further experiments, have revealed new details on the scope of the unfolded protein response and its connection to the degradation of proteins at the endoplasmic reticulum.