Biology for the post-genomic era

Fully Open Access. Genome Biology covers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research, new methods and software tools, and reviews, opinions and commentaries. Areas covered include, but are not limited to: sequence analysis; bioinformatics; insights into molecular, cellular and organismal biology; functional genomics; epigenomics; population genomics; proteomics; comparative biology and evolution; systems and network biology; genomics of disease; and clinical genomics. All content is open access immediately on publication.


  • Louisa Flintoft PhD, Genome Biology


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  • 3D chromatin rearrangements

    Signal-induced binding of glucocorticoid receptor and NFkappaB induce long-range rearrangements of chromatin

    Genome Biology 2015, 16:264
  • HiC-Pro

    HiC-Pro is an analysis tool for HiC data, for all stages from mapping reads to generating contact maps

    Genome Biology 2015, 16:259
  • Barley CRISPR editing

    Targeted, heritable mutations are achieved in barley and Brassica oleracea with the CRISPR-Cas system

    Genome Biology 2015, 16:258
  • Microbiome profiling from biopsies

    Doron Betel and colleagues describe methodology for the identification of pathogens from low bacterial abundance human WGS datasets

    Genome Biology 2015, 16:265
  • CRISPR design and analysis

    Daniel Graham and David Root review the tools for the design and analysis of CRISPR genome editing experiments

    Genome Biology 2015, 16:260
  • Down syndrome methylation

    Novel biological mechanisms are implicated in the development of Down syndrome by studying methylation patterns in humans and mice

    Genome Biology 2015, 16:263
  • S. aureus alternative Cas9

    A characterization of an alternative, Staphylococcus aureus-derived Cas9 nuclease and the design of all-in-one vector

    Genome Biology 2015, 16:257
  • p16 DNA methylation drives metastasis

    Engineered zinc finger methyltransferases provide insights into the role of p16 methylation in cancer metastasis

    Genome Biology 2015, 16:252
  • Cas9 PAM characterization

    A new in vitro method for simultaneous examination of guide RNA and PAM requirements for CRISPR-based experiments

    Genome Biology 2015, 16:253
  • Global fight with infectious diseases

    Amy Cain and John Lees report from the Infectious Disease Genomics conference on the applications of genomics to human health

    Genome Biology 2015, 16:250
  • Novel CRISPR nuclease

    Peter Fineran and colleagues discuss the discovery and the biotechnological potential of a novel endonuclease, Cpf1

    Genome Biology 2015, 16:251
Genome Editing: read the special issue
Single-cell omics: call for papers
Wheat genomics: featured research
3D Organization of the Nucleus
Avian Genomes collection

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ISSN: 1474-760X