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1: Nature. 1989 May 25;339(6222):280-6.
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The role of cyclin synthesis and degradation in the control of maturation promoting factor activity.

Murray AW, Solomon MJ, Kirschner MW.

Department of Biochemistry and Biophysics, School of Medicine, University of California, San Francisco 94143-0448.

We show that cyclin plays a pivotal role in the control of mitosis. A proteolysis-resistant mutant of cyclin prevents the inactivation of maturation promoting factor and the exit from mitosis both in vivo and in vitro. We have used a fractionated extract to study the activation of MPF by added cyclin protein.

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PMID: 2566918 [PubMed - indexed for MEDLINE]