Biology for the post-genomic era

Fully Open Access. Genome Biology covers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research, new methods and software tools, and reviews, opinions and commentaries. Areas covered include, but are not limited to: sequence analysis; bioinformatics; insights into molecular, cellular and organismal biology; functional genomics; epigenomics; population genomics; proteomics; comparative biology and evolution; systems and network biology; genomics of disease; and clinical genomics. All content is open access immediately on publication.


  • Louisa Flintoft PhD, Genome Biology


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  • Image attributed to: A panel of clinicians

    Diagnosing Mendelian diseases

    Advantages over clinical exome sequencing can be achieved by using an NGS-based multiplexing assay involving comprehensive gene panels.

    Genome Biology 2015, 16:134
  • Read length cost-benefit

    An analysis finds that increasing the read length for RNA-seq studies does not improve ability to detect differential expression

    Genome Biology 2015, 16:131
  • FOXM1 in chromatin recruitment

    The DNA binding domain of the Forkhead transcription factor FOXM1 is essential for binding to non-consensus sequences through protein-protein interactions.

    Genome Biology 2015, 16:130
  • Marrying microfluidics & microwells

    Alex Shalek and colleagues describe the latest developments in the microfluidic technology enabling single-cell sequencing studies

    Genome Biology 2015, 16:129
  • Breast cancer-stroma interactions

    A systems level analysis of epithelial-stromal interactions in invasive breast cancer reveals the co-expression self-loops

    Genome Biology 2015, 16:128
  • Cancer therapy response

    A single-cell transcriptomic analysis of lung adenocarcinoma patient derived xenografts reveals heterogeneity in the response to anti-cancer drugs

    Genome Biology 2015, 16:127
  • Circular RNA detection

    A new algorithm detects circular RNAs with high sensitivity and specificity and discovers human fetal brain regions enriched for circular RNA isoforms

    Genome Biology 2015, 16:126
  • Image attributed to: Genome engineering

    Genome synthesis and engineering

    In this Review, Srinivasan Chandrasegaran and colleagues explore the exciting advances in DNA synthesis and assembly methods made over the past decade.

    Genome Biology 2015, 16:125
  • Ultra-large alignments

    UPP is a method for ultra-large multiple sequence alignments using phylogeny-aware profiles, based on an ensemble of hidden Markov models

    Genome Biology 2015, 16:124
  • VTRNA2-1 environmental epiallele

    A screen for DNA methylated regions affected by season of conception in rural Gambia identifies VTRNA2-1 as an environmental epiallele

    Genome Biology 2015, 16:118
  • Imp co-ordinates F-actin

    iCLIP in Drosophila shows that Imp RNPs participate in actin cytoskeletal remodeling

    Genome Biology 2015, 16:123
Genome Editing
3D Organisation of the nucleus
Genome Biology Single Cell
Genomics of infectious diseases: special issue
Avian Genomes collection
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ISSN: 1465-6906