Biology for the post-genomic era

Fully Open Access. Genome Biology covers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research, new methods and software tools, and reviews, opinions and commentaries. Areas covered include, but are not limited to: sequence analysis; bioinformatics; insights into molecular, cellular and organismal biology; functional genomics; epigenomics; population genomics; proteomics; comparative biology and evolution; systems and network biology; genomics of disease; and clinical genomics. All content is open access immediately on publication.


  • Louisa Flintoft PhD, Genome Biology


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  • Large-scale RNAi screens

    Beerenwinkel and colleagues describe a method identifying hits from large-scale RNAi screens and removing confounding effects due to miRNA-mediated off-target interactions

    Genome Biology 2015, 16:220
  • Standing variation and adaptation

    Selective sweep mapping in chickens reveals that standing genetic variation makes a considerable contribution to the long-term response to selection

    Genome Biology 2015, 16:219
  • Translational regulation of malaria

    Bunnik and Le Roch highlight a Genome Biology study identifying PfAlba1 as a key regulator of translation during the blood stage of Plasmodium falciparum infection

    Genome Biology 2015, 16:221
  • XIST and localization

    Expression of XIST from exogenous sites induces perinuclear localization at each site, plus a variable extent of silencing

    Genome Biology 2015, 16:208
  • tRNAs and inherited conditions

    Work on primordial dwarfism provides new insights into links between tRNA modification and inherited conditions in humans

    Genome Biology 2015, 16:216
  • New genes drive evolution

    A new study identifies how new genes have driven the evolution of gene-gene interaction networks in vertebrates

    Genome Biology 2015, 16:202
  • Intestinal epigenetic regulation

    DNA methylation is functionally involved in the regulation of transcriptional activation in intestinal stem cells and is guided by the microbiome

    Genome Biology 2015, 16:211
  • Nanopore-based isoform identification

    Nanopore MinION sequencing is used to identify isoforms expressed from four different Drosophila genes

    Genome Biology 2015, 16:204
  • Cancer chromatin contacts

    Breast cancer cells show altered chromatin interactions, particularly among small, gene-rich chromosomes and at telomeres, compared with epithelial cells

    Genome Biology 2015, 16:214
  • Heterochromatin protein 1beta

    HP1beta has different roles and localization on chromatin in pluripotent and differentiated cells

    Genome Biology 2015, 16:213
  • Post-transcriptional regulation in malaria

    Deep sequencing identifies the PfAlba1 RNA-binding protein as an important regulator of translational timing in Plasmodium falciparum blood stages

    Genome Biology 2015, 16:212
3D Organization of the Nucleus
Single-cell omics: call for papers
Wheat genomics: featured research
Avian Genomes collection

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ISSN: 1474-760X