Biology for the post-genomic era

Fully Open Access. Genome Biology covers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research, new methods and software tools, and reviews, opinions and commentaries. Areas covered include, but are not limited to: sequence analysis; bioinformatics; insights into molecular, cellular and organismal biology; functional genomics; epigenomics; population genomics; proteomics; comparative biology and evolution; systems and network biology; genomics of disease; and clinical genomics. All content is open access immediately on publication.


  • Louisa Flintoft PhD, Genome Biology


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  • Global chromatin SUMOylation

    Palvimo and colleagues demonstrate that SUMOylation of chromatin-bound proteins represses heat shock-induced gene transcription

    Genome Biology 2015, 16:153
  • Transcript isoform abundance

    A comprehensive comparison of 11 tools for transcript isoform quantification using simulated data and experimentally derived data from RNA-seq and A-seq protocols

    Genome Biology 2015, 16:150
  • HiCap

    HiCap is a high resolution method, combining sequence capture and Hi-C, for identifying enhancer-promoter interactions

    Genome Biology 2015, 16:156
  • hiBA-FISH break detection

    hiBA-FISH is a high-throughput method for automatically detecting DNA breaks and translocations in FISH images

    Genome Biology 2015, 16:146
  • Cancer 3D chromatin changes

    Estrogen receptor is linked to long-range changes in higher-order chromatin organisation and epigenetic dysregulation in breast cancer

    Genome Biology 2015, 16:145
  • Real-time pathogen surveillance

    Jennifer Gardy, Nick Loman and Andrew Rambaut's call to arms: new technologies should be better used to aid public health surveillance

    Genome Biology 2015, 16:155
  • EpiCSeg

    A method for segmentation of epigenomes into chromatin states using ChIP-seq data

    Genome Biology 2015, 16:151
  • SUPeR-Seq

    A new method for single-cell poly(A)-independent RNA-seq unravels the circRNA landscape in mouse preimplantation embryos

    Genome Biology 2015, 16:148
  • Kiwi genome

    The kiwi genome provides insights into how the bird adapted to a nocturnal lifestyle and its other remarkable features

    Genome Biology 2015, 16:147
  • Reproducibility matters

    Genome Biology and other BioMed Central journals are piloting a new checklist for enhancing reproducibility.

    Genome Biology 2015, 16:141
  • Arabidopsis genome editing

    New approach uses egg cell-specific promoter-controlled CRISPR/Cas9 to efficiently generate homozygous mutants for multiple target genes in Arabidopsis in a single generation

    Genome Biology 2015, 16:144
Genome Editing
3D Organisation of the nucleus
Genome Biology Single Cell
Genomics of infectious diseases: special issue
Avian Genomes collection
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ISSN: 1474-760X