Biology for the post-genomic era

Fully Open Access. Genome Biology covers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research, new methods and software tools, and reviews, opinions and commentaries. Areas covered include, but are not limited to: sequence analysis; bioinformatics; insights into molecular, cellular and organismal biology; functional genomics; epigenomics; population genomics; proteomics; comparative biology and evolution; systems and network biology; genomics of disease; and clinical genomics. All content is open access immediately on publication.


  • Louisa Flintoft PhD, Genome Biology


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  • RNA-seq quantification errors

    Comparing 12 methods for estimating gene expression from RNA-Seq data identifies hundreds of genes whose expression is underestimated by one or more methods

    Genome Biology 2015, 16:177
  • SMRT sequencing in plants

    Combination of SMRT and Illumina reads provide comprehensive gene sets for newly sequenced genomes of non-model organisms sugar beet and spinach

    Genome Biology 2015, 16:184
  • Hi-C analysis methods

    Ferhat Ay and William Noble review computational tools for analyzing Hi-C data

    Genome Biology 2015, 16:183
  • Retinopathy phenotype severity

    Phenotype severity in mouse models of CRX-associated retinopathies correlates with graded gene expression changes

    Genome Biology 2015, 16:171
  • Predicting nuclear organization

    Oliver Cuvier discusses two recent Genome Biology articles which present methods for predicting aspects of nuclear organization from epigenetic data

    Genome Biology 2015, 16:182
  • 3Dome editorial

    Special issue guest editors Peter Fraser and David Gilbert discuss the state of the field and the articles in the issue

    Genome Biology 2015, 16:181
  • Predicting chromatin compartments

    A method for predicting a sequence’s localization in the A or B compartment of the nucleus based on chromatin data

    Genome Biology 2015, 16:180
  • Barley domestication

    Robin Allaby discusses the origins of barley, and what this means for our understanding of the evolution of domesticated crops

    Genome Biology 2015, 16:176
  • In-nucleus ligation Hi-C

    A comparison of in-nucleus and in-solution ligation protocols for Hi-C finds that the former gives much more consistent results

    Genome Biology 2015, 16:175
  • Chromatin and lamins

    Susan Gasser and colleagues discuss how the nuclear lamina interacts with chromatin and the implications this has for nuclear organization

    Genome Biology 2015, 16:174
  • Barley landrace origins

    A new study increases our understanding of the evolutionary genetic process associated with the transition from wild to domesticated barley

    Genome Biology 2015, 16:173
3D Organization of the Nucleus
Genome Editing
Genome Biology Single Cell
Genomics of infectious diseases: special issue
Avian Genomes collection

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ISSN: 1474-760X