An inter-laboratory meta-analysis of more that 500 microarrays from the liver and kidney of control rats defined key sources of variability in control animals and will aid in the efficient design of future toxicogenomics experiments.
By comparing an organism's chromosomes to those of closely related species using a segmentation algorithm, breakpoints can be precisely delimited and their internal structure described, providing insights into the mechanisms and evolutionary properties of chromosomal rearrangements.
Hepatotoxin responses Lobenhofer EK, Auman JT, Blackshear PE, Boorman GA, Bushel PR, Cunningham ML, Fostel JM, Gerrish K, Heinloth AN, Irwin RD, et al. / 20 June 2008
Histopathology, clinical chemistry, hematology and gene expression data were collected from the rat liver and blood after treatment with eight known hepatotoxins.
Profiling of gene expression changes in mice harbouring the neurodegenerative Wlds mutation shows a strong correlation between changes in cell cycle pathways and altered vulnerability of terminally differentiated neurons.
A systematic analysis of histone modifications between human segmental duplications shows that two seemingly identical genomic copies have distinct epigenomic properties.
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